Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
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84 citations
TL;DR: A relationship between position and depth of the electrostatic minima relative to the azabicyclic ring and the potency and efficacy of the compounds was determined.
Abstract: The synthesis of 15 methyl or unsubstituted 1,2,3-triazoles, 1,2,4-triazoles, and tetrazoles additionally substituted with a 1-azabicyclo[2.2.2]octan-3-yl group is described. The potency and efficacy of these compounds as muscarinic ligands were determined in radioligand binding assays using [3H]oxotremorine and [3H]quinuclidinyl benzilate. Potency and efficacy were found in compounds in which the azole moiety was attached to the azabicyclic ring either through a carbon atom or a nitrogen atom. Electrostatic potential maps of both the C-linked and the novel N-linked series of compounds were calculated. A relationship between position and depth of the electrostatic minima relative to the azabicyclic ring and the potency and efficacy of the compounds was determined.
84 citations
84 citations
TL;DR: Venustatriol (1 ) has been synthesized by an enantioselective and convergent route via key intermediates 9 and 15 as discussed by the authors, and it has been shown that it can be synthesized using a key intermediate.
84 citations
TL;DR: A new type of (4+3) cycloaddition strategy based on the platinumor gold-catalyzed intramolecular reaction of allene-tethered dienes such as 1 is reported, which represents the first example of an intramsolecular, highly enantioselective (4C + 3C) cycloadeddition.
Abstract: Allene-tethered dienes undergo entitled cycloaddition by treatment with a suitable chiral Au—phosphoramidite catalyst to provide synthetically valuable fused bicyclic systems with high diastereoselectivity and excellent enantioselectivities.
84 citations