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Bicyclic molecule

About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.


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Journal ArticleDOI
TL;DR: In this paper, the Schmidt reaction was used to generate bridged-or fused-bicyclic a-amino carbocations or iminium ions, depending on the geometry about the C(+)-N bond.
Abstract: Aliphatic azides were captured intramolecularlyby carbocations, producing aminodiazonium ion intermediates. Carbon-to-nitrogen rearrangement then occurred, generating bridged- or fused-bicyclic a-amino carbocations or iminium ions, depending on the geometry about the C(+)-N bond. In the bridged systems, rapid elimination of the α-amino carbocations produced twisted enamines with 1-azabicyclo[3.2.2]nonene, 1-azabicyclo[2.2.2]octene, and 1-azabicyclo[3.2.1]octeneskeletons. In the fused systems, the iminium ions were reduced with sodium borohydridetogive 1-azabicyclo [n.3.0]alkanes, where n=4 or 5. The carbocations for these intramolecular Schmidt reactions were generated by treatment of alkenes or alcohols with trifluoromethanesulfonic acid

83 citations

Patent
04 Feb 2010
TL;DR: In this paper, the authors proposed novel benzodiazepine derivatives with antiproliferative activity and provided cytotoxic dimers of these compounds, as well as compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal.
Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

83 citations

Patent
22 Dec 2006
TL;DR: In this paper, the general formula (I) in which the variable groups are as defined herein, and their preparation and use is described. But this work is restricted to compounds of I.
Abstract: This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.

83 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023206
2022476
2021237
2020259
2019304
2018283