Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
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TL;DR: A series of bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl] alkanes have been synthesized and were converted into bis-[1,0,3-b]-1,3,4 -thiadiazol-4-yl alkanes which exhibited activity with MIC in the range 3-12.5 micrograms/ml.
Abstract: A series of bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl] alkanes have been synthesized and were converted into bis-[1,2,4-triazolo[3,4-b]-1,3,4-thiadiazol-4-yl] alkanes. The newly synthesized compounds were characterized by analytical IR, NMR and mass spectral studies. Some of the newly synthesized compounds were screened for their antibacterial properties and exhibited activity with MIC in the range 3–12.5 μg/ml.
80 citations
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18 Jan 1996TL;DR: In this paper, the authors proposed a method for the inhibition of platelet aggregation using six membered rings of a bicyclic compound, such as benzopyran, iso-quinoline, isoquinoline or tetrahydronaphthalene.
Abstract: This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
80 citations
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TL;DR: The toluene oxidation mechanism was shown to have a strong oxygen concentration dependence, presumably due to the central role of the bicyclic peroxy radical in determining the stable product distribution at atmospheric oxygen concentrations, and a potential role for bicyclicperoxy radical + HO(2) reactions at high HO( 2)/NO ratios is suggested.
Abstract: The products of the primary OH-initiated oxidation of toluene were investigated using the turbulent flow chemical ionization mass spectrometry technique under different oxygen, NO, and initial OH radical concentrations as well as a range of total pressures. The bicyclic peroxy radical intermediate, a key proposed intermediate species in the Master Chemical Mechanism (MCM) for the atmospheric oxidation of toluene, was detected for the first time. The toluene oxidation mechanism was shown to have a strong oxygen concentration dependence, presumably due to the central role of the bicyclic peroxy radical in determining the stable product distribution at atmospheric oxygen concentrations. The results also suggest a potential role for bicyclic peroxy radical + HO2 reactions at high HO2/NO ratios. These reactions are postulated to be a source of the inconsistencies between environmental chamber results and predictions from the MCM.
80 citations
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TL;DR: The cyclization of 2'-aminochalcone (2a) and its side-chain additives has been studied for the development of syntheses of 2-aryl-4-quinolones.
Abstract: The cyclization of 2'-aminochalcone (2a) and its side-chain additives has been studied for the development of syntheses of 2-aryl-4-quinolones. 2a and its 2'-acetamido 2b and 2'-benzenesulfonamido 2c derivatives underwent acid- or base-catalyzed cyclization to 1,2,3,4-tetrahydro-4-quinolones
80 citations