Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
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TL;DR: In this paper, les auteurs decrivent la synthese enantioselective de la (+)-brefeldine C. C. utilise une amine chirale: la (t-butyl-2 methyl-4 phenyl-5) oxazolidine
Abstract: Les auteurs decrivent la synthese enantioselective de la (+)-brefeldine C. Cette synthese utilise une amine chirale: la (t-butyl-2 methyl-4 phenyl-5) oxazolidine
76 citations
TL;DR: In this article, cyclopentanone reacts with arylidenemalononitriles to give dihydro-4,6-indenedicarboxylate derivative.
76 citations
76 citations
TL;DR: Using a B-alkyl Suzuki cross-coupling as a key step, a concise and stereocontrolled synthesis of five- to eight-membered triisopropylsiloxy ethers having (2Z)-(6,6-dimethoxyhexylidene) or (5,5-Dimethoxypentylidenes) side chains was developed, with high stereo- and enantioselectivity.
Abstract: Using a B-alkyl Suzuki cross-coupling as a key step, a concise and stereocontrolled synthesis of five- to eight-membered triisopropylsiloxy ethers having (2Z)-(6,6-dimethoxyhexylidene) or (2Z)-(5,5-dimethoxypentylidene) side chains was developed. Prins-pinacol reactions of these precursors promoted by SnCl4 provide bicyclic products in which 5-, 6-, or 7-membered rings are joined by a C−C single bond. Synthetically challenging attached ring systems in which both rings are chiral can be prepared in this fashion with high stereo- and enantioselectivity. Stabilizing through-space electrostatic interactions between the α-alkoxycarbenium ion and an axially positioned oxygen substituent are believed to play a significant role in organizing the transition structure of the Prins cyclization.
76 citations
TL;DR: A new strategy employing the van Leusen three-component reaction and the ring-closing metathesis reaction in a sequential fashion to access fused bicyclic imidazole rings is reported, generating compounds of significant molecular complexity from simple starting materials in an expedient fashion with excellent yields.
76 citations