Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
Papers published on a yearly basis
Papers
More filters
TL;DR: The proline-derived N-sulfonylcarboxamide-catalyzed direct enantioselective α-oxidation of ketones and aldehydes with nitrosobenzene is presented in this paper.
73 citations
TL;DR: In this article, the synthesis of 19 new compounds, 2-arylamino-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidines 9, and the results of their potassium-sparing diuretic activity are reported
73 citations
Patent•
14 Jun 2001TL;DR: In this paper, the authors proposed a method of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders which contain the compounds (1), where R?1, R3, R4, R5, R11?, m and p are as defined as defined herein.
Abstract: The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R?1, R3, R4, R5, R11?, m and p are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
73 citations
TL;DR: 6-alkylidene substituted 4-heteryldithio and 4-methylsulfonyl azetidin-2-ones revealed potent cytotoxic properties towards monolayer tumor cells in <10-microM concentrations.
73 citations
TL;DR: The structures of newly synthesized compounds were confirmed on the basis of their elemental analysis and spectral data results (IR, 1H-and 13C NMR) and some of the compounds exhibited promising antimicrobial activities.
73 citations