Topic
Bicyclic molecule
About: Bicyclic molecule is a research topic. Over the lifetime, 29587 publications have been published within this topic receiving 451252 citations. The topic is also known as: bicyclic molecule.
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360 citations
TL;DR: The existence of a structurally degenerate Cope rearrangement of bicyclo[5.1.1] octa-2,4-diene at room temperature is revealed by the examination of the N.M.R. spectrum.
351 citations
TL;DR: In this paper, a series of 3,5-bis(arylidene)-4-piperidones, as chalcone analogues carrying variety of aryl and heteroaryl groups, were synthesized and screened for their in vitro antiviral and antitumor activities at the National Cancer Institute (NCI).
Abstract: A new series of 3,5-bis(arylidene)-4-piperidones, as chalcone analogues carrying variety of aryl and heteroaryl groups, pyrazolo[4,3-c]pyridines, pyrido[4,3-d]pyrimidines, and pyrido[3,2-c]pyridines, carrying an arylidene moiety, and a series of pyrano[3,2-c]pyridines, as flavone and coumarin isosteres, were synthesized and screened for their in vitro antiviral and antitumor activities at the National Cancer Institute (NCI). Compounds 9 and 18 proved to be active against herpes simplex virus-1 (HSV-1), while compound 13 showed moderate activity against human immunodeficiency virus-1 (HIV-1). Compounds 14, 26, 28, 33, and 35 exhibited a broad spectrum antitumor activity. In addition, compounds 26, 33, and 35 proved to be of moderate selectivity toward leukemia cell lines. The pyrano[3,2-c]pyridines heterocyclic system proved to be the most active antitumors among the investigated heterocycles.
349 citations
Patent•
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TL;DR: A hair dye composition containing a triazene dissociative direct dye represented by general formula (1): A-N=N-NH-B (1) wherein A and B are each a monocyclic or a bicyclic aromatic heterocyCLIC group that may have a substituent or a moncyclic or bicyclic aryl group as discussed by the authors.
Abstract: A hair dye composition containing a triazene dissociative direct dye represented by general formula (1): A-N=N-NH-B (1) wherein A and B are each a monocyclic or a bicyclic aromatic heterocyclic group that may have a substituent or a monocyclic or a bicyclic aryl group that may have a substituent and contain none of a carboxy group, a sulfo group and a quaternary ammonium group; and A and B each bind to a triazene-1,3-diyl group represented by -N=N-NH- via a carbon atom within A and B each. A and B may be the same or different.
347 citations
TL;DR: Reduction de la chloro-2 acetophenone en presence de diphenyl-5,5 trimethylene-3,4 oxazaborolidine-1,3,2 suivie de dechlorhydratation as discussed by the authors.
Abstract: Reduction de la chloro-2 acetophenone en presence de diphenyl-5,5 trimethylene-3,4 oxazaborolidine-1,3,2 suivie de dechlorhydratation
334 citations