Topic
Biomphalaria alexandrina
About: Biomphalaria alexandrina is a research topic. Over the lifetime, 413 publications have been published within this topic receiving 3781 citations.
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TL;DR: The study of the genome focuses on finding an alternative natural source instead of the chemical molluscicides and controlling the intermediate host to reduce the transmission.
Abstract: ARTICLE INFO Article History: Received: March 8, 2020 Accepted: March 30, 2020 Online: April 3, 2020 _______________
1 citations
Journal Article•
1 citations
01 Jan 2014
TL;DR: It is found that the DNA of susceptible snails was more effective in protecting against schistosomiasis than either susceptible or resistant snails.
Abstract: The aim of the present work is to evaluate the role of DNA of either susceptible or resistant Biomphalaria alexandrina snails as a vaccine in Schistosoma mansoni infected mice. The evaluation was done through estimation of parasitological, biochemical and histopathological parameters in S. mansoni infected mice liver. The results revealed that malondialdehyde (MDA), xanthin oxidase (OX), glucose-6phosphatase (G-6Pase), acid phosphatase (AP) and 5` nucleoprotein (5`Nu) are significantly increased in S. mansoni infected mice, while glutathione (GSH), vitamin C and E, glutathione reductase (GR), superoxide dismutase (SOD), catalase, succinate and lactate dehydrogenase (SDH & LDH) showed significant reduction after infection. Alternation of the energetic parameters (ATP, ADP, AMP, phosphate potentials, inorganic phosphate), amino acid fractions and LDH isoenzymes were also noticed. The work was extended to measure ova and worm counts as well as the histopathological picture of liver. Vaccination of S. mansoni infected mice with DNA of either susceptible or resistant snails, recorded amelioration levels of the selected parameters by variable degrees. In conclusion, we found that the DNA of susceptible snails was more effective in protecting against schistosomiasis. Further examinations of the DNA constituents must be performed to identify the specific target responsible for protection against infection.
1 citations
Journal Article•
TL;DR: Selection of progenies from infected B.alexandrina and B.truncatus snails resulted in higher infection rates, consistent when the source of micardia were from either infected human or hamsters.
Abstract: Selection of progenies from infected B.alexandrina and B.truncatus snails resulted in higher infection rates. This observation was consistent when the source of micardia were from either infected human or hamsters. Infection rate of B.alexandrina increased up to 88.2% while B.truncatus did not. Compatibility between the parasites and their intermediate hosts were also studied.
1 citations