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Bioprocess

About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.


Papers
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Journal ArticleDOI
TL;DR: An overview about importance and benefits of solid-state fermentation is presented, pointing out this bioprocess as an alternative technology for use agro-industrial by-products as substrates to produce valuable secondary metabolites and their applications as food quality conservatives.
Abstract: Agro-industrial by-products are important sources of potent bioactive phenolic compounds. These compounds are of extreme relevance for food and pharmacological industries due to their great variety of biological activities. Fermentation represents an environmentally clean technology for production and extraction of these bioactive compounds, providing high quality and high activity extracts, which can be incorporated in foods using coatings/films wax-based in order to avoid alterations in their quality. In this document is presented an overview about importance and benefits of solid-state fermentation, pointing out this bioprocess as an alternative technology for use agro-industrial by-products as substrates to produce valuable secondary metabolites and their applications as food quality conservatives.

26 citations

Book ChapterDOI
TL;DR: Wood, agricultural residues and waste liquors constitute a cheap source of renewable raw materials for industrial solvent production, and hexose- and pentose-based polysaccharides are readily utilized for this purpose.
Abstract: Metabolic activities of some anaerobic Clostridia strains result in the production of solvents, acetone, butanol, ethanol, iso-propanol etc., and hydrogen gas, all of interest to industry. Hexose sugars are readily utilized for this purpose, so are hexose- and pentose-based polysaccharides. Pentoses can also be utilized, however, the production rates observed are somewhat lower. Revived interest in the process is currently gaining momentum and new techniques of genetic manipulation of microorganisms coupled together with novel bioprocess technology, solvent recovery techniques, and minicomputer process control/optimization, offer a promise of resulting in an efficient and competitive process modification. Wood, agricultural residues and waste liquors constitute a cheap source of renewable raw materials for industrial solvent production.

26 citations

Journal ArticleDOI
TL;DR: The results in this article establish the utility of multimodal chromatography when used with appropriate mobile phase modifiers for the downstream bioprocessing of a modified human growth hormone and offer new approaches for biopROcess verification.
Abstract: This study demonstrates how the multimodal Capto adhere resin can be used in concert with calcium chloride or arginine hydrochloride as mobile phase modifiers to create a highly selective purification process for a modified human growth hormone Importantly, these processes are shown to result in significant clearance of product related aggregates and host cell proteins Furthermore, the steric mass action model is shown to be capable of accurately describing the chromatographic process and the aggregate removal Finally, justification of the selected operating ranges is evaluated using the model together with Latin hypercube sampling The results in this article establish the utility of multimodal chromatography when used with appropriate mobile phase modifiers for the downstream bioprocessing of a modified human growth hormone and offer new approaches for bioprocess verification

26 citations

Journal ArticleDOI
TL;DR: Methods of adapting micro-organisms to an inhibiting factor in an active industrial bioprocess were examined with an acetic acid fermentation as model and a fuzzy-logic system was developed on the basis of the collected knowledge of skilled vinegar brewers for automatic control.

26 citations

Journal ArticleDOI
TL;DR: Improvements act to improve the biotechnological engineering cycle with tools for building, testing and evaluating cell factories and bioprocesses by increasing throughput, parallelization and automation.

26 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023331
2022785
2021165
2020153
2019159
2018127