Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
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TL;DR: The tool identified the most cost-effective scalable cell culture technologies used in the manufacture of lentiviral vectors (LVs) across a range of products and highlighted the impact of increasing the specific productivity in the FB on COGLV/dose for transient transfection and stable producer cell line scenarios.
19 citations
TL;DR: It is argued for the appropriateness of using software agents for the monitoring and control of bioprocesses using different approaches to the design of individual agents as well as complete multi-agent systems.
Abstract: We argue for the appropriateness of using software agents for the monitoring and control of bioprocesses. Different approaches to the design of individual agents as well as complete multi-agent systems are discussed. This is followed by a brief discussion of a number of successful agent-based monitoring and control applications from different domains. We conclude by discussing the advantages and disadvantages of agent technology for monitoring and control of bioprocesses.
© 2002 Society of Chemical Industry
19 citations
TL;DR: In this paper, the authors describe a successful pilot-scale proof-of-concept demonstration of an end-to-end integrated and continuous bioprocess for the production of a monoclonal antibody (mAb).
Abstract: There has been increasing momentum recently in the biopharmaceutical industry to transition from traditional batch processes to next-generation integrated and continuous biomanufacturing. This transition from batch to continuous is expected to offer several advantages which, taken together, could significantly improve access to biologics drugs for patients. Despite this recent momentum, there has not been a commercial implementation of a continuous bioprocess reported in the literature. In this study, we describe a successful pilot-scale proof-of-concept demonstration of an end-to-end integrated and continuous bioprocess for the production of a monoclonal antibody (mAb). This process incorporated all of the key unit operations found in a typical mAb production process, including the final steps of virus removal filtration, ultrafiltration, diafiltration, and formulation. The end-to-end integrated process was operated for a total of 25 days and produced a total of 4.9 kg (200 g/day or 2 g/L BRX/day) of the drug substance from a 100-L perfusion bioreactor (BRX) with acceptable product quality and minimal operator intervention. This successful proof-of-concept demonstrates that end-to-end integrated continuous bioprocessing is achievable with current technologies and represents an important step toward the realization of a commercial integrated and continuous bioprocessing process.
19 citations
TL;DR: In this paper , the authors summarize the recent scientific and biotechnological progresses on astaxanthin biosynthetic pathways, transcriptional regulations, the interrelation with lipid metabolism, engineering strategies as well as fermentation process control in major native and non-native producers.
19 citations
TL;DR: Existing mathematical models for sulphate reduction are reviewed, focusing on models for biofilms, microbial competition, inhibition and bioreactor dynamics as well as for biomass activity and composition.
Abstract: In the sulphate-reducing process, bioprocess control can be used to regulate the competition between microbial groups, to optimize the input of the electron donor and/or to maximize or minimize the production of sulphide. As shown in this review, modelling and monitoring are important tools in the development and application of a bioprocess control strategy. Pre-eminent literature on modelling, monitoring and control of sulphate-reducing processes is reviewed. This paper firstly reviews existing mathematical models for sulphate reduction, focusing on models for biofilms, microbial competition, inhibition and bioreactor dynamics. Secondly, a summary of process monitoring strategies is presented. Special attention is given to in situ sensors for sulphate, sulphide and electron donor concentrations as well as for biomass activity and composition. Finally, the state of the art of the bioprocess control strategies in biological sulphate reduction processes is overviewed.
19 citations