Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
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TL;DR: In this article , the authors reviewed the factors influencing simultaneous nitrification-denitrification (SND) and its application in biofilm systems from laboratory to full scale, and provided operational strategies to enhance SND efficiency and hints to reduce nitrogen oxide emission and operational costs.
19 citations
TL;DR: An efficient and green bioprocess is reported to obtain halogenated nucleosides by transglycosylation using immobilized lactic acid bacteria (LAB) to synthesize 5-fluorouracil-2′-deoxyriboside (floxuridine).
Abstract: An efficient and green bioprocess is herein reported to obtain halogenated nucleosides by transglycosylation using immobilized lactic acid bacteria (LAB). Lactobacillus animalis ATCC 35046 showed a yield of 95% at 0.5 h to synthesize 5-fluorouracil-2′-deoxyriboside (floxuridine). Calcium alginate was the best matrix for whole-cell immobilization by entrapment. Its productivity was 87 mg/L h in a continuous bioprocess. When adsorption techniques were evaluated, DEAE-Sepharose was the support which showed higher microbial load, its productivity being 53 mg/L h. Additionally, this microorganism was able to produce 5-bromouracil-2′-deoxyriboside, 6-chloropurine-2′-deoxyriboside and 6-bromopurine-2′-deoxyriboside.
19 citations
TL;DR: Impacts of a careful and extensive process control are shown by a fully automated repetitive batch culture of Saccharomyces cerevisiae grown on defined medium and results on the excellent reproducibility of biotechnological experiments underline the new quality of this concept.
19 citations
TL;DR: The improvement in the rate of production and yield of acetic acid resulted from the alleviation of the inhibitory effect, on metabolism of the microbe, of the acetic Acid that is produced, by maintaining a favorable pH and a low level of acetics acid in the reaction mixture by electrodialysis.
19 citations