Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
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TL;DR: An integrated techno-economic analysis assessing the feasibility of affinity purification technologies using the manufacture of induced pluripotent stem cell-derived progenitor photoreceptors for retinal dystrophies as a case study and technical and bioprocess benefits were noted with SpheriTech beads which require no cell labeling.
Abstract: Aim: To present an integrated techno-economic analysis assessing the feasibility of affinity purification technologies using the manufacture of induced pluripotent stem cell-derived progenitor photoreceptors for retinal dystrophies as a case study. Materials & methods: Sort purity, progenitor yield and viable cell recovery were investigated for three cell sorting techniques: fluorescent-activated cell sorting (FACS); magnetic-activated cell sorting (MACS); and a novel technology SpheriTech beads. Experimentally derived metrics were incorporated into an advanced bioprocess economics tool to determine cost of goods per dose for each technology. Results & conclusion: Technical and bioprocess benefits were noted with SpheriTech beads which, unlike FACS and MACS, require no cell labeling. This simplifies the bioprocess, reduces cell loss and leaves target cells label free. The economic tool predicted cost drivers and a critical dose (7 × 107 cells per dose) shifting the most cost-effective technology from FACS...
17 citations
TL;DR: In this paper , low-cost microfluidics devices have been used to accelerate early bioprocess design, achieving high strain screening throughput with low titres with low mass transfer and product quality.
17 citations
TL;DR: A competitive production method using the biotransformation of 4-butyrobetaine to enantiomerically pure L-carnitine was developed and scaled up by Lonza and found to be economically the most favourable process mode.
Abstract: A competitive production method using the biotransformation of 4-butyrobetaine to enantiomerically pure L-carnitine was developed and scaled-up by Lonza The process produces L-carnitine in 995% yield, and >999% enantiomeric excess (ee) Continuous and discontinuous processes were developed but the fed-batch process was found to be economically the most favourable process mode
17 citations
30 Mar 2016
TL;DR: The present paper describes the bioprocess strategies involved in the application and production of enzymes from industrial biotechnology perspectives from industrialBiotechnology perspectives.
Abstract: The present paper describes the bioprocess strategies involved in the application and production of enzymes from industrial biotechnology perspectives. Several enzymes are produced from different microbial sources and there are several chemical reactions occur with the help of enzymes within very short time. Bioprocess technology is the key factor to use enzymes in different purposes and also produce under different circumstances. Therefore, it is very important to discuss the synopsis of these issues on a same platform for future references.
16 citations
TL;DR: Invention of sample preparations and protein database developments are enhancing the quantity and accuracy of proteomic results, and innovations in proteomics are enriching biotechnology and bioprocessing research across a wide spectrum of applications.
16 citations