Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
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TL;DR: In this article, the biomass of the marine dinoflagellate microalga Amphidinium carterae was used to assess and optimise three different methods in order to obtain three families of high-value biochemical compounds present in the biomass.
15 citations
TL;DR: A pragmatic approach to PAT monitoring that serves both development and manufacturing stages is proposed and it is shown how more accurate calibrations can be obtained using Clone-based local models, which requires less batches than usual approaches.
15 citations
TL;DR: In this paper , an integrated SDAD-Anammox model was developed to describe the interactions between sulfur-oxidizing bacteria and Anammox bacteria and was subsequently used to explore the impacts of influent conditions on the reactor performance and microbial community structure of the anoxic reactor.
15 citations
TL;DR: The utilisation of solid-state bioprocessing using the fungus Trichoderma longibrachiatum was implemented as a simultaneous microbial pretreatment and in-situ enzyme production method for fungal autolysis and further enzyme hydrolysis of fermented solids.
15 citations
TL;DR: This work measured the single-cell lipid production dynamics in a time-invariant microfluidic environment and discovered that production is not monotonic, but rather sporadic with time, and linked such intracellular production fluctuations with cell-to-cell productivity diversity in culture.
Abstract: Bioprocess limitations imposed by microbial cell-to-cell phenotypic diversity remain poorly understood. To address this, we investigated the origins of such culture diversity during lipid production and assessed the impact of the fermentation microenvironment. We measured the single-cell lipid production dynamics in a time-invariant microfluidic environment and discovered that production is not monotonic, but rather sporadic with time. To characterize this, we introduce bioprocessing noise and identify its epigenetic origins. We linked such intracellular production fluctuations with cell-to-cell productivity diversity in culture. This unmasked the phenotypic diversity amplification by the culture microenvironment, a critical parameter in strain engineering as well as metabolic disease treatment.
15 citations