Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: The selective release of products is reviewed and discussed as a possible means of improving the efficiency of downstream processing.
140 citations
TL;DR: Proper understanding and rigorous analysis of several engineering parameters would pave the way towards the successful commercialization of plant cell bioprocesses.
Abstract: Plant cell culture provides a viable alternative over whole plant cultivation for the production of secondary metabolites. In order to successfully cultivate the plant cells at large scale, several engineering parameters such as, cell aggregation, mixing, aeration, and shear sensitivity are taken into account for selection of a suitable bioreactor. The media ingredients, their concentrations and the environmental factors are optimized for maximal synthesis of a desired metabolite. Increased productivity in a bioreactor can be achieved by selection of a proper cultivation strategy (batch, fed-batch, two-stageetc.), feeding of metabolic precursors and extraction of intracellular metabolites. Proper understanding and rigorous analysis of these parameters would pave the way towards the successful commercialization of plant cell bioprocesses.
139 citations
TL;DR: A set of genetic tools that are useful in the engineering of customized phage-defence systems are described, with special focus on the power of comparative genomics as a means of streamlining target selection, providing more widespread phage protection, and increasing the longevity of these industrially important bacteria in the bioprocessing environment.
Abstract: Bacteriophages (phages) have the potential to interfere with any industry that produces bacteria as an end product or uses them as biocatalysts in the production of fermented products or bioactive molecules. Using microorganisms that drive food bioprocesses as an example, this review will describe a set of genetic tools that are useful in the engineering of customized phage-defence systems. Special focus will be given to the power of comparative genomics as a means of streamlining target selection, providing more widespread phage protection, and increasing the longevity of these industrially important bacteria in the bioprocessing environment.
138 citations
TL;DR: A knowledge based software, named BIOESTIM, is presented; the facilities offered by this software, which includes expertise in system analysis and estimation theory, show it is a powerful tool in Computer Aided Estimation of bioprocesses.
135 citations
TL;DR: The technology involved in the bioprocess is discussed and the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals are described.
132 citations