Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
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Patent•
14 Jan 2005
TL;DR: In this article, a bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.
Abstract: A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.
14 citations
TL;DR: In this article, the authors deal with the heat integration of a bioprocess plant which produces yeast and ethyl-alcohol using batch pinch analysis and the use of the Time slice model.
14 citations
Patent•
04 Jul 2002
TL;DR: In this paper, a bioprocess where aggregation of spheroid-forming cells, such as embryonic stem cells and spheroids, is controlled by encapsulation of within a matrix is proposed.
Abstract: The present inventors identified aggregation of embryonic stem cells and embryoid bodies (EBs) as the cause of the difficulty in generating large numbers of the embryonic stem cells (ES) cell-derived tissues To counter this, the invention provides a novel bioprocess where aggregation of spheroid-forming cells, such as embryonic stem cells and spheroids, such as EBs is controlled, such as by encapsulation of within a matrix As a result, EBs can be generated with high efficiency and cultured in high cell density, well-mixed systems Well-mixed conditions facilitate measurement and control of the bulk media conditions and allow for the use of scalable bioreactor systems for clinical production of tissue Therefore, the invention enables generation of ES cell-derived tissue on a clinical scale The invention is also applicable to any spheroid-forming cells and other types of pluripotent cells
14 citations
TL;DR: Kinetic analysis and molecular docking clearly indicated that chlorine substitution in the pyridine ring of nicotinamide, especially the substitution at 2-position led to a dramatic decrease of Pa-Ami activity, implying that Pa- ami is potentially promising biocatalyst for industrial production of 2-CA.
14 citations
TL;DR: A fully automated robotic facility with 24 parallel mini-bioreactors that is operated by a model-based adaptive input design framework for the characterization of clone libraries under scale-down conditions, based on a macro-kinetic growth model that is continuously re-fitted to the available experimental data.
Abstract: In bioprocess development, the host and the genetic construct for a new biomanufacturing process are selected in the early developmental stages. This decision, made at the screening scale with very limited information about the performance in larger reactors, has a major influence on the efficiency of the final process. To overcome this, scale-down approaches during screenings that show the real cell factory performance at industrial-like conditions are essential. We present a fully automated robotic facility with 24 parallel mini-bioreactors that is operated by a model-based adaptive input design framework for the characterization of clone libraries under scale-down conditions. The cultivation operation strategies are computed and continuously refined based on a macro-kinetic growth model that is continuously re-fitted to the available experimental data. The added value of the approach is demonstrated with 24 parallel fed-batch cultivations in a mini-bioreactor system with eight different Escherichia coli strains in triplicate. The 24 fed-batch cultivations were run under the desired conditions, generating sufficient information to define the fastest-growing strain in an environment with oscillating glucose concentrations similar to industrial-scale bioreactors.
14 citations