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Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
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TL;DR: Analysis of experimental data on continuous fermentation of sucrose and glucose solution at low pH to gluconic acid by Asprgillus niger immobilized on cellulose fabric provides a mathematical model for predicting values of conversion 5, 10 and 15 h ahead of conversion.
Abstract: Experimental data on continuous fermentation of sucrose and glucose solution at low pH to gluconic acid by Asprgillus niger immobilized on cellulose fabric show complex dynamic behaviour including a decline in yield. The data have been analyzed using an artificial intelligence based symbolic regression technique to provide a mathematical model for predicting values of conversion 5, 10 and 15 h ahead values of conversion. These predictions can be used during continuous operations to monitor the bioprocess and adjust the residence time of fermentation to get complete and more efficient conversion of sucrose or glucose to gluconic acid.
13 citations
TL;DR: In this article , the authors mainly discussed the recent advances in enzyme immobilization employing representative nanomaterials, including silica-based nanomorphs, carbon-based nano-materials, metal-based and magnetic nanommaterials.
Abstract: Enzymes seem to be ideal biocatalysts in various bioprocessing fields due to their eco-friendliness and nonhazardous merits. Generally, enzymological characteristics such as catalytic activity, selectivity, specificity, and stability often become weak in extreme processing conditions. Enzymes immobilized onto support materials through the physical, chemical, and physicochemical mechanisms can overcome these limitations. Compared with macroscopic supports, inorganic nanomaterials show great superiority in enzyme immobilization due to their specific physicochemical properties, such as large surface area, pore diameter, mechanical resistance, and so on. Herein, this paper mainly talks about recent advances in enzyme immobilization employing representative nanomaterials, including silica-based nanomaterial, carbon-based nanomaterial, metal-based nanomaterial, and magnetic nanomaterial. The prospective and opportunities of these materials applied in the food-processing industry are also discussed to promote immobilization technological innovation.
13 citations
TL;DR:
Abstract: Fucoxanthin attracts increasing attentions due to its potential health benefits, which has been exploited in several food commodities. However, fucoxanthin available for industrial application is mainly derived from macroalgae, and is not yet sufficiently cost-effective compared with microalgae. This review focuses on the strategies to improve fucoxanthin productivity and approaches to reduce downstream costs in microalgal production. Here we comprehensively and critically discuss ways and methods to increase the cell growth rate and fucoxanthin content of marine microalgae, including strain screening, condition optimization, design of culture mode, metabolic and genetic engineering, and scale-up production of fucoxanthin. The approaches in downstream processes provide promising alternatives for fucoxanthin production from marine microalgae. Besides, this review summarizes fucoxanthin improvements in solubility and bioavailability by delivery system of emulsion, nanoparticle, and hydrogel, and discusses fucoxanthin metabolism with gut microbes. Fucoxanthin production from marine microalgae possesses numerous advantages in environmental sustainability and final profits to meet incremental global market demands of fucoxanthin. Strategies of adaptive evolution, multi-stage cultivation, and bioreactor improvements have tremendous potentials to improve economic viability of the production. Moreover, fucoxanthin is promising as the microbiota-targeted ingredient, and nanoparticles can protect fucoxanthin from external environmental factors for improving the solubility and bioavailability.
13 citations
13 citations
TL;DR: First indications on a reduced growth rate of the cells due to immobilization were found and parameters relevant for process design such as reproducibility of simultaneously performed cultures, optimal dilution rate and long-term performance were determined.
Abstract: The multi-fixed-bed bioreactor “Multiferm” provides a downscaled system for the development of fixed-bed processes with immobilized microorganisms or cells. It consists of twelve single fixed-bed units that can be operated independently. Different bacterial strains, carriers used for immobilization, media or flow rates can be studied in one compact experimental set-up. Experiments can be run in parallel to allow for determination of experimental errors. In these studies several continuous cultivations were carried out with Lactobacillus delbrueckii ssp. bulgaricus using different dilution rates and culture durations as proof-ofconcept for the Multiferm. Parameters relevant for process design such as reproducibility of simultaneously performed cultures, optimal dilution rate and long-term performance were determined by means of volume specific lactate and biomass productivity. First indications on a reduced growth rate of the cells due to immobilization were found.
13 citations