Topic
Bioprocess
About: Bioprocess is a research topic. Over the lifetime, 2219 publications have been published within this topic receiving 50972 citations.
Papers published on a yearly basis
Papers
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DSM1
TL;DR: Here it is tried to highlight what can be learned from real large-scale bioprocess in combination with model fluid studies, and to provide suitable computation tools to overcome data restrictions.
Abstract: For industrial bioreactor design, operation, control and optimization, the scale-down approach is often advocated to efficiently generate data on a small scale, and effectively apply suggested improvements to the industrial scale. In all cases it is important to ensure that the scale-down conditions are representative of the real large-scale bioprocess. Progress is hampered by limited detailed and local information from large-scale bioprocesses. Complementary to real fermentation studies, physical aspects of model fluids such as air-water in large bioreactors provide useful information with limited effort and cost. Still, in industrial practice, investments of time, capital and resources often prohibit systematic work, although, in the end, savings obtained in this way are trivial compared to the expenses that result from real process disturbances, batch failures, and non-flyers with loss of business opportunity. Here we try to highlight what can be learned from real large-scale bioprocess in combination with model fluid studies, and to provide suitable computation tools to overcome data restrictions. Focus is on a specific well-documented case for a 30-m(3) bioreactor. Areas for further research from an industrial perspective are also indicated.
100 citations
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TL;DR: This paper investigates the construction of artificial network-based biomass and penicillin estimators for on-line application to an industrial fermentation by considering the ability of artificial neural networks to learn essential process non-linearities from plant data.
100 citations
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TL;DR: The recent advances, trends and problems in optical sensors, including the latest laser and infrared probes, are summarized and alternative methods, such as multiple-extinction fluorimetry, real-time imaging and particle-size analysis, are discussed.
98 citations
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TL;DR: The present review discusses the literature on upstream processing, bioprocessing, product recovery and applications of pullulan.
97 citations
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01 Jan 1998
TL;DR: This paper presents a review of the literature on biosensors used in clinical analysis, applications to bioprocess industry, and applications to environmental samples.
Abstract: APPLICATIONS TO CLINICAL SAMPLES. Biosensors for Personal Diabetes Management (T. Henning & D. Cunningham). Microfabricated Sensors and the Commercial Development of the i--Stat Point--of--Care System (G. Davis). Noninvasive Biosensors in Clinical Analysis (G. Palleschi, et al.). Surface Plasmon Resonance (R. Earp & R. Dessy). Biosensors Based on Evanescent Waves (D. Purvis, et al.). APPLICATIONS TO BIOPROCESS SAMPLES. Applications of Biosensor--Based Instruments to the Bioprocess Industry (J. Woodward & R. Spokane). APPLICATIONS TO ENVIRONMENTAL SAMPLES. Application of Biosensors to Environmental Samples (K. Riedel). Index.
96 citations