Topic
Bioreactor
About: Bioreactor is a research topic. Over the lifetime, 9980 publications have been published within this topic receiving 192690 citations. The topic is also known as: bioreactors.
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TL;DR: This work presents a multiphysics computational model for the prediction of cartilage tissue growth in an interstitial perfusion bioreactor and shows that all parameters predicted, such as oxygen concentration and wall shear stress, by the 2D sub-model are systematically overestimated and thus the tissue growth, which directly depends on these parameters.
Abstract: The main challenge in engineered cartilage consists in understanding and controlling the growth process towards a functional tissue. Mathematical and computational modelling can help in the optimal design of the bioreactor configuration and in a quantitative understanding of important culture parameters. In this work, we present a multiphysics computational model for the prediction of cartilage tissue growth in an interstitial perfusion bioreactor. The model consists of two separate sub-models, one two-dimensional (2D) sub-model and one three-dimensional (3D) sub-model, which are coupled between each other. These sub-models account both for the hydrodynamic microenvironment imposed by the bioreactor, using a model based on the Navier-Stokes equation, the mass transport equation and the biomass growth. The biomass, assumed as a phase comprising cells and the synthesised extracellular matrix, has been modelled by using a moving boundary approach. In particular, the boundary at the fluid-biomass interface is moving with a velocity depending from the local oxygen concentration and viscous stress. In this work, we show that all parameters predicted, such as oxygen concentration and wall shear stress, by the 2D sub-model with respect to the ones predicted by the 3D sub-model are systematically overestimated and thus the tissue growth, which directly depends on these parameters. This implies that further predictive models for tissue growth should take into account of the three dimensionality of the problem for any scaffold microarchitecture.
68 citations
TL;DR: The membrane bioreactor is an emerging technology for the reclamation of municipal wastewater that combines the desorption and recovery of phosphorous with the recovery of nitrogen in a membrane-based system.
Abstract: A pilot-scale membrane bioreactor sufficiently purified simulated municipal wastewater for indirect recharge to groundwater or nonpotable uses. Throughout more than 500 days of steady-state operation, total organic carbon concentrations of <1.1 mg/L and chemical oxygen demand of <3.5 mg/L were consistently achieved. No suspended solids were detected in the effluent during this period. The treated water was fully nitrified, resulting in low ammonia and organic nitrogen concentrations but high nitrate concentrations. Cyclic oxic-anoxic operation of an additional denitrification process would be necessary to meet potable water reuse standards. Phosphorus was fully used in the bioreactor for biological growth. Heterotrophic bacteria and MS-2 viruses were completely retained by the membrane system, reducing the extent of final disinfection required.
67 citations
TL;DR: This work presents a mixed population phototrophic model for domestic wastewater treatment in anaerobic conditions and assesses the process by analyzing a continuous reactor simulation scenario within a long-term wastewater treatment system in a photo-anaerobic membrane bioreactor.
67 citations
TL;DR: In this study, agricultural residues including wheat straw, corn stalk and sugarcane bagasse were investigated for the improvement of isFBB, and cane bagasse was demonstrated to be the best immobilization material.
67 citations
TL;DR: The successful integration of AnMBRs in a treatment train that addresses the critical challenges of dissolved methane and nutrients demonstrates the viability of the technology in achieving holistic wastewater treatment.
Abstract: Concerns regarding ambient temperature operation, dissolved methane recovery, and nutrient removal have limited the implementation of anaerobic membrane bioreactors (AnMBRs) for domestic wastewater...
67 citations