Topic
Bioreactor
About: Bioreactor is a research topic. Over the lifetime, 9980 publications have been published within this topic receiving 192690 citations. The topic is also known as: bioreactors.
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TL;DR: In this paper, a tubular bioreactor integrated with the membrane distillation (MD) system was investigated for ethanol production in a yeast-based membrane bioreactors, and the authors found that the removal of by-products from the fermenting broth by MD process increased the efficiency and the rate of sugar conversion to ethanol.
66 citations
TL;DR: It is demonstrated that high-density mammalian cell cultures could be maintained for long-term protein production without pH control and culture pH could be potentially modulated via adjusting residual glucose levels and CO2 stripping capability in perfusion cultures.
66 citations
TL;DR: In this paper, a 0.4-μm hollow-fiber membrane module submerged in an aeration tank and bacteriophage MS-2 was used as the indicator organism.
66 citations
TL;DR: An enzyme-NBD@MOF bioreactor with exemplary proteolytic performance, even after successive reuse and storage, was produced through a novel, rapid and simple multipoint immobilization technique without chemical modification of the solid support.
Abstract: An enzyme-NBD@MOF bioreactor with exemplary proteolytic performance, even after successive reuse and storage, was produced through a novel, rapid and simple multipoint immobilization technique without chemical modification of the solid support. Enzyme loading and distribution could be directly monitored from the fluorescence emission of the bioreactor. The dye molecular dimension plays a role in its overall performance.
65 citations
TL;DR: The results reveal the suitability of the Mobius® CellReady 3L bioreactor for cell expansion and protein production with animal cell cultures and enable comparisons with other single‐use and reusable cell culture bioreactors at bench‐scale.
Abstract: Stirred single-use bioreactors can be used as substitutes for their conventional counterparts made of glass or stainless steel in the development and production of biopharmaceuticals wherever possible. Various studies have confirmed their comparability in cell growth as well as in product quantity and quality. However, information about their engineering characteristics is still rare. This study focuses on the stirred Mobius® CellReady 3L bioreactor. The main engineering parameters for typical operation conditions used in animal cell cultivations are presented for the first time. Numerical simulations with a commercial CFD package (Fluent 6.3) were accomplished to obtain data on the single- and multi-phase fluid flow, power input, mixing time and oxygen mass transfer. The results, which were compared with data from experiments and from the literature, reveal the suitability of the Mobius® CellReady 3L bioreactor for cell expansion and protein production with animal cell cultures. Furthermore, the data enable comparisons with other single-use and reusable cell culture bioreactors at bench-scale.
65 citations