Topic
Bistability
About: Bistability is a research topic. Over the lifetime, 12251 publications have been published within this topic receiving 227528 citations. The topic is also known as: bistable.
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TL;DR: It is demonstrated that in the absence of any imposed feedback regulation, bistability and hysteresis can arise solely from a distributive kinetic mechanism of the two-site MAPK phosphorylation and dephosphorylation.
Abstract: itogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two different stable states MAPK cascades are often embedded in positive feedback loops, which are considered to be a prerequisite for bistable behavior Here we demonstrate that in the absence of any imposed feedback regulation, bistability and hysteresis can arise solely from a distributive kinetic mechanism of the two-site MAPK phosphorylation and dephosphorylation Importantly, the reported kinetic properties of the kinase (MEK) and phosphatase M (MKP3) of extracellular signal‐regulated kinase (ERK) fulfill the essential requirements for generating a bistable switch at a single MAPK cascade level Likewise, a cycle where multisite phosphorylations are performed by different kinases, but dephosphorylation reactions are catalyzed by the same phosphatase, can also exhibit bistability and hysteresis Hence, bistability induced by multisite covalent modification may be a widespread mechanism of the control of protein activity
746 citations
TL;DR: Differential gain and large hysteresis have been seen in the transmission of a Fabry-Perot interferometer containing Na vapor irradiated by light from a cw dye laser.
Abstract: Differential gain and large hysteresis have been seen in the transmission of a Fabry-Perot interferometer containing Na vapor irradiated by light from a cw dye laser. Non-linear dispersion, neglected in earlier work, dominates over nonlinear absorption in Na. The apparatus uses only optical inputs and outputs. Similar apparatus may be useful as an optical amplifier, memory element, clipper, and limiter.
733 citations
TL;DR: In this paper, a non-resonant piezomagnetoelastic energy harvester with high-energy orbits was proposed and investigated over a range of excitation frequencies.
700 citations
IBM1
TL;DR: In this paper, the operation of a bistable switch that derives its function from the motion of a single atom is reported. But the switch is a prototype of a new class of potentially very small electronic devices which we will call atom switches.
Abstract: THE scanning tunnelling microscope1 (STM) has been employed in recent years in attempts to develop atomic-scale electronic devices, both by examining device-like characteristics in preexisting structures2,3 and by creating new structures by the precise manipulation of atoms and molecules with the STM tip4–6. Here we report the operation of a bistable switch that derives its function from the motion of a single atom. A xenon atom is moved reversibly between stable positions on each of two stationary conducting 'leads', corresponding to the STM tip and a nickel surface. The state of the switch is set (that is, the xenon atom is moved to the desired location) by the application of a voltage pulse of the appropriate sign across the leads. The state of the switch is identified by measuring the conductance across the leads. This switch is a prototype of a new class of potentially very small electronic devices which we will call atom switches.
695 citations
TL;DR: In this paper, the authors demonstrate a self-stable equilibrium solution for a pump-microcavity system, where intensity and wavelength perturbations cause a small thermal resonant-drift that is enough to compensate for the perturbation.
Abstract: As stability and continuous operation are important for almost any use of a microcavity, we demonstrate here experimentally and theoretically a self-stable equilibrium solution for a pump-microcavity system. In this stable equilibrium, intensity- and wavelength-perturbations cause a small thermal resonant-drift that is enough to compensate for the perturbation (noises); consequently the cavity stays warm and loaded as perturbations are self compensated. We also compare here, our theoretical prediction for the thermal line broadening (and for the wavelength hysteretic response) to experimental results.
694 citations