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Showing papers on "Blisters published in 1990"


Journal Article
TL;DR: It is suggested that rupture of the epidermis can initiate the Koebner response, but that secondary dermal events are necessary for a psoriatic lesion to form.
Abstract: The Koebner phenomenon was studied using low pressure suction and/or sellotape stripping. Each of 10 patients with psoriasis had 5 suction blisters induced and sellotape stripping. In each patient the roof of 4 of the 5 blisters was removed. In 6 of the 10 patients, psoriasis developed where the blister roof was removed, but not where the blister was left intact. However, only 3 of these 10 patients were also Koebner-positive at the tape-stripped site. Similarly, in a group of 37 psoriasis patients who were sellotape-stripped alone, only 8 (21.6%) were Koebner-positive at the tape-stripped site. In another experiment, 5 suction blisters were produced in each of 4 patients. The roof of 4 blisters was removed, one of which was occluded. Psoriasis developed in 3 of the 4 patients, but only where the blister roof had been removed and left unoccluded. These findings suggest that rupture of the epidermis can initiate the Koebner response, but that secondary dermal events are necessary for a psoriatic lesion to form.

33 citations


Journal Article
TL;DR: A patient suffering from generalized morphea developed blisters in the morpheic plaques on her buttocks, which had an increased concentration of serum aminoterminal propertice of type III procollagen, an echo response and thickened skin on ultrasound scanning, and compact bundles of collagen fibrils with bimodal distribution of the diameters.
Abstract: A patient suffering from generalized morphea developed blisters in the morpheic plaques on her buttocks. The plaques had an increased concentration of serum aminoterminal propertice of type III procollagen, an echo response and thickened skin on ultrasound scanning, and compact bundles of collagen fibrils with bimodal distribution of the diameters. The blisters appeared as an echo-free band in the subepidermal zone by ultrasound scanning. Electron microscopy revealed blisters in the upper papillary dermis, surrounded by degraded collagen fibrils.

9 citations


Journal Article
TL;DR: The consistent results of the standardized suction blister method makes this method useful for studying drug penetration to extravascular compartments in humans.
Abstract: The suction blister technique was used for pharmacokinetic studies with sulfonamides and trimethoprim. Blisters produced by suction (-0.3 kg/cm2) for 1.5 h contained approximately 0.15 ml fluid with a protein content of 40-50% of that in plasma, the main protein fractions being present in the same ratio as in plasma. 2 g sulfaisodimidine was given as bolus injection, i.v. infusion or orally to groups of 4 volunteers. The peak blister fluid concentrations after oral administration (120 +/- 18 mmol/l) was only marginally lower than the concentrations after i.v. infusion (122 +/- 28 mmol/l) and i.v. bolus injections (134 +/- 37 mmol/l). The total drug blister fluid concentration started to decrease before the plasma level was reached. However the relative concentration increased from 53% of that in plasma at 8 h to 66% at 12 h after drug administration. Considering the protein binding of the drugs, the interstitial fluid levels of free drug were presumably higher than the plasma level after 8 h. Comparison of drug concentrations in blisters produced before and after the drugs were given showed higher concentrations in the latter for the first 2-6 h. However, after 8-12 h the concentrations of the drugs in the two types of blisters were similar. The suction blister method produces blisters of uniform size. The drug concentrations in different experiments showed the coefficient of variation for blister fluid concentrations to be no greater than for plasma levels. The consistent results of the standardized suction blister method makes this method useful for studying drug penetration to extravascular compartments in humans.

8 citations


Patent
20 Dec 1990
TL;DR: In this article, the authors describe a line for packaging products in blisters made in a band of polypropylene, where a device is used to carry out the heat sealing of a film (2) onto the blister band (3).
Abstract: In a line (4) for packaging products in blisters (3a) made in a band (3) of polypropylene, a device (1) carries out the heat sealing of a film (2) onto the blister band (3). The device comprises a frame (7) supporting an upper plate (8) and a lower plate (9) with hollows (9a) suited to receive the blisters (3a). When the hollows (9a) match against the blisters (3a) of the overlying band (3) the plates (8,9) are brought near to each other so as to clamp, in a sealing station (P), the interposed film (2) and blister band (3). The device (1) allows the moving of the sealing station along the advancement direction (A) of the band (3) according to the longitudinal shortening of the band with respect to the steady state operation of the line (4).

6 citations


Journal ArticleDOI
TL;DR: In this paper, the authors investigated the mechanisms responsible for surface blistering in evaporated alumina thin films after xenon irradiation and proved that the substrate-alumina interface is not responsible for blistering.
Abstract: Blisters have been observed in evaporated alumina thin films after xenon irradiation. The aim of this study is to further understand the mechanisms responsible of such process. Surface blistering dependence on thickness of the alumina films as well as irradiation fluence, temperature and post-irradiation thermal annealing have been investigated. From our experimental results, it has been proved that the substrate-alumina interface is not responsible for blistering. Also, according to the gas pressure model and the lateral compressive stress model the latter seems to be more adequate to explain blister formation.

3 citations


Journal ArticleDOI
TL;DR: In this article, the shape of blisters formed in bilayer optical storage media due to the buildup of thermal stresses during laser writing was calculated using finite element analysis, and it was shown that practically usable blisters may be expected to form in a time period of about 15 ns.
Abstract: Finite element analysis is used to calculate the shape of blisters formed in bilayer optical storage media due to the buildup of thermal stresses during laser writing. It is shown that practically usable blisters may be expected to form in a time period of about 15 ns. Such a thermal stress delamination process may also precede melting in conventional pit formation processes.

2 citations