Blisters

About: Blisters is a research topic. Over the lifetime, 980 publications have been published within this topic receiving 16229 citations.

Device for accommodating a drug blister

Abstract: The present invention relates to a novel device for accommodating and storing blister packs, particularly pharmaceutical blisters, and for releasing a tablet or capsule from the blister pack using a means for punching the cover film of the blister.

Study of buckling and delamination of ductile thin films on rigid substrates

Abstract: Thin film coatings submitted to high compressive stresses may experience a simultaneous buckling and delamination phenomenon called "blistering". The mechanism of formation and propagation of blisters in the form of straight wrinkles and circular blisters has been extensively studied in the literature considering a linear elastic behavior for the film. However, the effect of plasticity on the propagation and mechanical equilibrium of such blisters, although experimentally observed, had not been systematically studied to date.In this work, we are interested in the observation and characterization of buckling structures observed on gold films deposited on silicon substrates. The effects of plasticity on the morphology or critical buckling load of buckled structures are quantitatively demonstrated using small scale surface observation techniques such as AFM, as well as mechanical testing by nanoindentation tests and stress measurement methods.A mechanical model is developed in order to model the film as a geometric nonlinear plate with elastic-plastic behavior in unilateral contact with a rigid support representing the substrate. In addition, a cohesive zone model is introduced between the plate and the support in order to take into account the delamination of the film, with a separation work depending on the mode mix of the interface loading.This model allowed us to highlight the effect of plasticity on the equilibrium profiles resulting from elastic-plastic blistering, for both straight and circular blisters morphologies. The effect on the offset of the critical buckling load has also been studied. Finally, the influence of plastic deformation on the propagation mechanism of the interfacial fracture itself has been studied. In particular, a stabilizing effect of the circular blister form, which has been observed experimentally in various studies, has been demonstrated through calculation.

Delayed and recurring blisters in the donor graft site of a burn patient - eScholarship

Abstract: A 79-year-old woman presented for evaluation of non-healing skin graft donor sites. The patient underwent split thickness skin graft repair two-and-a-half years ago as a consequence of severe burns from a fire that affected 10 to 15 percent of her body. Donor sites included her thighs and flanks. After initial healing, intermittent and paroxysmal, eroded and crusted, erythematous plaques have continued to arise at various donor sites. Normal skin has remained uninvolved. Histopathologic analysis showed a poor basement membrane zone. The patient's findings represented delayed and recurring blistering in the donor graft site that is uncommonly observed in burn patients.