Blisters

About: Blisters is a research topic. Over the lifetime, 980 publications have been published within this topic receiving 16229 citations.

Experimental Validation for the Theory of Blisters’ Instabilities

Abstract: Blister formation is a universal problem that can be witnessed within a wide range of contents. It is first documented as a side effect of syringomyelia and other diseases. Later on, the forming of blisters are also observed during the cell apoptosis, which leads to the hypothesis that it could have some intricate relationships with the death of living organisms. Other than biological problems, blister forming is also a common phenomenon in thin film technologies. Therefore, the research in the forming of blisters is essential and critical in both engineering and science fields. In this thesis, we study the problem of a growing blister made of a rubber-like membrane adhered on a rigid substrate, and the implications that it might have on possible artificial shapemorphing skins. We show that a blister test is a problem driven by competition between two instabilities: one inherent to the rubber, and second one pertaining to the adhesion with the substrate. This enables obtaining different results with such that the final blister profile can be perfectly controlled by only adjusting the thickness of the film and the inflation rate. Given the theory, the rest part of this thesis is mainly focused on the experimental validation of it. We designed our unique experimental systems to analyze such problem and by matching the experimental results and simulation results, we can verify the validity of our theory.

Dry powder inhaler with blister bursting device

Abstract: A multi-dose dry powder inhaler with a blister folding device is provided. The inhaler comprises a housing containing a blister strip, and a blister opening device. The blister strip comprises a plurality of individual blisters, each blister containing a dose of medicament for inhalation by a user. The blister opening device comprising a blister support element for supporting one of said blisters, and a blister folding element co-operable with the blister support element, the blister folding element and the blister support element being movable relative to each other between a first position, permitting movement of said blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element. Movement from the first position to the second position causes two spaced apart portions of said blister to each fold relative to the remainder of the blister to produce two spaced apart openings, each opening extending along the circumference of the blister bowl, beginning and terminating at points located on the fold line No piercing of the blister at any stage is required.

Bullous Disorder - An Ayurvedic review study

Abstract: Vesicles and bullae are accumulation of fluid within or under the epidermis. Blisters, whether large bullae or small vesicles, can arise in a variety of conditions. Blisters may result from destruction of epidermal cells (a burn or a herpes virus infection). Loss of adhesion between the cells may occur within the epidermis (pemphigus) or at the basement membrane (pemphigoid). Sometimes, there are associated inflammatory changes in the dermis (erythema multiforme/vasculitis) or a metabolic defect (as in porphyria). In Ayurveda all skin disease have been described under the umbrella of Kustha. Kushtha is divided into two types Maha Kushtha and Kshudra Kushtha. Mahakushtha again divided in to seven types and Kshudra Kushtha into eleven types. Out of eleven types Vishphot is one of them. Vesiculobullous disorder resemble to Vishphot. The objective of this article is to analyze Vishphot and Charmadal its etiology, etiopathogenesis, management from different Ayurvedic literature. Though Vishphot and Charmadal is included under Kushta, hence etiology, etiopathogenesis, and management are same. Sapta Dravya i.e., Three Dosha and Tvak, Rakta, Mamsa, Lasika plays an important role in etiopathogenesis of Kushtha as well as Vishphot having predominance Pitta Kapha Dosha.

Carrying of a combination containing tiotropium in a blister strip

Abstract: Present invention relates to a method for effective dosing of a medicament in dry powder form that comprises a combination of tiotropium' and formoterol, from blisters that are placed adjacently onto the peelable blister strip, wherein only one of the blisters are opened prior to inhalation.