Topic
Blisters
About: Blisters is a research topic. Over the lifetime, 980 publications have been published within this topic receiving 16229 citations.
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TL;DR: In this model, blister removal eliminated any therapeutic effect of cooling or dipyridamol; in burns with blisters intact, absorbed heat appeared at least as detrimental to healing as stasis, and some of the beneficial effects of cooling appeared unrelated to prevention of stasis.
Abstract: To appraise the ability of each to improve wound healing in zone-of-stasis burns (i.e., burns becoming progressively more ischemic early postburn), 1) an antithromboxane (dipyridamol PO immediately postburn), 2) burn-wound cooling, 3) their combination, or 4) no treatment was administered to burned guinea pigs half of which had burn blisters removed immediately postburn (PB). In all groups with blisters removed whole-thickness or very deep partial-thickness skin loss occurred. In all groups with blisters intact complete reversal of ischemia occurred without necrosis and, while dipyridamol and cooling each diminished stasis early PB, only cooled wounds showed any improved retention of hair follicles at 3 weeks PB. In this model, therefore: 1) blister removal eliminated any therapeutic effect of cooling or dipyridamol; 2) in burns with blisters intact, absorbed heat appeared at least as detrimental to healing as stasis, and 3) some of the beneficial effects of cooling appeared unrelated to prevention of stasis.
39 citations
TL;DR: Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blister, based on histological, electrolyte and protein findings.
Abstract: 1.
Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings.
2.
Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs between blister fluid and serum follows the laws of diffusion.
3.
The investigations suggest that blister fluid resembles interstitial fluid and can therefore serve as a model for the estimation of drug concentrations in interstitial fluid.
39 citations
Patent•
22 Apr 1997
TL;DR: In this article, an unburstable security strip is used to ensure that individual blisters are opened in a predetermined sequence, and printed indicia are included to indicate the manner in which the first blister of the sequence can be opened.
Abstract: A blister pack includes an unburstable security strip (17) which ensures that individual blisters are opened in a predetermined sequence. Printed indicia are included to indicate the manner in which the first blister of the sequence can be opened. The pack is suitable for pharmaceutical tablets and provides resistance to unauthorized opening by children.
39 citations
Patent•
26 Oct 2004
TL;DR: Dry powder blister packages include sealed blisters that incorporate or cooperate with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion as mentioned in this paper.
Abstract: Dry powder blister packages include sealed blisters that incorporate or cooperate with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.
39 citations
TL;DR: In this article, a range of laser fluence was found in which a blister or domelike feature was produced where the oxide film was delaminated from the substrate, and the blister features were analyzed with optical and atomic force microscopy.
Abstract: Silicon (100) substrates with thermal oxide films of varying thickness were irradiated with single and multiple 150 fs laser pulses at normal and non-normal incidences. A range of laser fluence was found in which a blister or domelike feature was produced where the oxide film was delaminated from the substrate. At normal and non-normal incidences blister features were observed for samples with 54, 147, and 1200 nm of thermal oxide. The blister features were analyzed with optical and atomic force microscopy. In addition, the time frame for blister growth was obtained using pump-probe imaging techniques.
38 citations