Blisters

About: Blisters is a research topic. Over the lifetime, 980 publications have been published within this topic receiving 16229 citations.

Does cantharides blister fluid provide access to the peripheral compartment

Abstract: The pharmacokinetics of bendroflumethiazide (BFT) was investigated following the oral administration of 10 mg to 3 healthy volunteers. Each subject participated twice in the study. BFT was determined in plasma and cantharides blister fluid from 1/2 to 30 h post administration. Blister fluid was obtained from blisters 10–22 h old. Plasma levels were fitted to a tri-exponential equation and the concentration of the drug in the peripheral compartment was calculated from the microscopic rate constants. In 5 of 6 cases investigated, cantharides blister fluid levels paralleled the concentration of the drug in the peripheral compartment. The mean blister fluid levels exceeded the calculated concentration in Compartment 2 1.46 fold. In one case, the blister fluid level paralleled the plasma level. This subject clearly differed from the others as more than 10 h were required for blister formation in her. The results suggest that following the administration of BFT, cantharides blister fluid behaves as part of the peripheral compartment. The possible value of studying blister fluid levels in pharmacokinetic investigations is discussed.

Micro-scale delaminating and buckling of thin film on soft substrate

Abstract: In this paper, a simple process is suggested to estimate the interfacial toughness of the material system ?aluminum film/soft PDMS substrate?. The specimen, i.e. the aluminum film deposited on the soft polydimethylsiloxane (PDMS) substrate, is subject to a tensile load, and delaminating and buckling of aluminum film are observed in the perpendicular direction to the tensile strain. With the aid of the buckling blisters, the interfacial toughness of the material system is estimated. Large deformation is considered during the buckling of the thin film, and the interfacial toughness is deduced from a fracture theory. Besides, the evolution from one single blister to three blisters and then four blisters is observed in situ under microscope. This simplified method has potential applications to flexible electronics in which interfacial toughness of the metal film/soft substrate must be well controlled.

Investigation of the influence of textiles and surface treatments on blistering using a novel simulant.

Abstract: Background: Friction blisters occur when shear loading causes the separation of dermal layers Consequences range from minor pain to life-threatening infection Past research in blister formation has focused on in vivo experiments, which complicate a mechanics-based study of the phenomenon Methods: A Synthetic Skin Simulant Platform (3SP) approach was developed to investigate the effect of textile fabrics (t-shirt knit and denim cottons) and surface treatments (dry and wet lubricants) on blister formation 3SP samples consist of bonded elastomeric layers that are surrogates for various dermal layers These layers display frictional and mechanical properties similar to their anatomical analogues Blistering was assessed by the measurement of deboned area between layers Results: Denim caused greater blistering than did the t-shirt knit cotton, and both lubricants significantly reduced blister area and surface damage A triglyceride-based lubricant had a more pronounced effect on blister reduction than corn starch The triglyceride lubricant used with t-shirt knit cotton resulted in no blisters being formed Conclusion: The performance of the 3SP approach follows previously reported frictional behavior of skin in vivo The results of textile and surface treatment performance suggest that future 3SP iterations can be focused on specific anatomical sites based on application type