Topic
Blood coagulation disorder
About: Blood coagulation disorder is a research topic. Over the lifetime, 117 publications have been published within this topic receiving 1421 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: Fibrinogen from a patient with a blood coagulation disorder has an amino-acid substitution (arginine to serine) in the vicinity of the bond split by thrombin during normal blood coagenation.
Abstract: Fibrinogen from a patient with a blood coagulation disorder has an amino-acid substitution (arginine to serine) in the vicinity of the bond split by thrombin during normal blood coagulation.
206 citations
TL;DR: This review did not find strong evidence to support an extensive work‐up for thrombophilic and coagulation diseases for the vast majority of patients, but when tests for common cardiovascular risk factors for RVO are negative, evaluation for potential coagulated disorders may be indicated.
Abstract: Retinal vein occlusion (RVO) is the second most common retinal vascular disease after diabetic retinopathy and is a common cause of visual morbidity and blindness in the elderly. A large proportion of patients with RVO have a history of cardiovascular disease, hypertension, diabetes mellitus or open-angle glaucoma. Although RVO is sometimes associated with thrombophilias and coagulation abnormalities, the role of coagulation factors in the development of RVO remains unclear. This review did not find strong evidence to support an extensive work-up for thrombophilic and coagulation diseases for the vast majority of patients. However, when tests for common cardiovascular risk factors for RVO are negative, evaluation for potential coagulation disorders may be indicated, particularly in young patients and in patients with bilateral RVO, a history of previous thromboses or a family history of thrombosis.
150 citations
TL;DR: The specific recruitment and functional roles of different immune cells, such as mast cells and leukocytes, in DVT are analyzed and it is speculated how immune modulation could be used for DVT prevention with a lower risk of bleeding complications than conventional therapeutic approaches.
112 citations
TL;DR: The cases reported here suggest a possible association of inherited APC resistance with ischemic stroke in young patients and the clinical history of these patients suggests that homozygosity for the defect is compatible with life and does not seem to be associated with early or more severe thrombophilia compared with homozygous defects of other clotting inhibitors.
Abstract: Background A new pathological condition termed “activated protein C (APC) resistance” has recently been reported to be the most common hereditary blood coagulation disorder associated with familial thrombosis. APC resistance is characterized by a poor anticoagulant response to APC in the plasma of patients and is due to a defect of factor V. Case Descriptions This report deals with three Italian families with inherited APC resistance in which stroke had occurred at a young age in one of the family members. One of the patients exhibited ischemic stroke at 8 months of age. Although deep vein thrombosis is considered the main clinical manifestation of the defect, its possible association with stroke is discussed. DNA analysis confirmed the presence of the 1691GA mutation in the factor V gene (factor V Leiden) in all patients with a normalized APC sensitivity ratio of less than 0.70. In three cases the APC sensitivity ratios were very low (approximately 1.2), with a normalized APC sensitivity ratio of approxi...
108 citations
TL;DR: A disulfide bond between the A2 domain and the A3 domain, preventing A2 subunit dissociation, has been engineered in FVIIIa to obtain increased stability and provides a unique approach for studies of the cofactor activity of FV IIIa and also for new, improved therapy for hemophilia A.
72 citations