Topic
Blood serum
About: Blood serum is a research topic. Over the lifetime, 46843 publications have been published within this topic receiving 993315 citations.
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TL;DR: A simple procedure which enables the sample to be inserted into the gel without any supporting substance and evidence is obtained that genetic factors are concerned in the control of the 'post-albumins' of different persons.
Abstract: Experience with the method of zone electrophoresis in starch gels (Smithies, 1955) suggests that the resolution of protein components is lessened by the use of supporting substances (e.g. filter paper or starch grains) to prevent electro-decantation from occurring during the entry of migrating proteins into the gels. The present paper describes a simple procedure which enables the sample to be inserted into the gel without any supporting substance. Electro-decantation is prevented by carrying out the electrophoresis with the gel in a vertical position. The resolution of serum proteins obtainable in the gels is considerably improved, and the difficulties of obtaining reproducible results are reduced. Evidence is obtained with the new technique that genetic factors are concerned in the control of the 'post-albumins' of different persons. (A) General view of cover (underside) d
1,231 citations
TL;DR: A brief review of current knowledge concerning some biochemical, physiological and medical aspects of the function of ubiquinone (coenzyme Q) in mammalian organisms can be found in this article.
1,197 citations
TL;DR: The function provides an economic and efficient method of identifying persons at high cardiovascular risk who need preventive treatment and persons at low risk whoneed not be alarmed about one moderately elevated risk characteristic.
Abstract: Persons at high risk of cardiovascular disease can be effectively identified from a measurement of their serum cholesterol and blood pressure, a smoking history, an electrocardiogram and a determination of glucose intolerance. One general function for identifying persons at high risk of cardiovascular disease is also effective in identifying persons at risk for each of the specific diseases, coronary heart disease, atherothrombotic brain infarction, hypertensive heart disease and intermittent claudication, even though the variables used have a different impact on each particular disease. The 10 percent of persons identified with use of this function as at highest risk accounted for about one fifth of the 8 year incidence of coronary heart disease and about one third of the 8 year incidence of atherothrombotic brain infarction, hypertensive heart disease and intermittent claudication. Hence the function provides an economic and efficient method of identifying persons at high cardiovascular risk who need preventive treatment and persons at low risk who need not be alarmed about one moderately elevated risk characteristic.
1,140 citations
TL;DR: The glycerol released by saponification of the serum glycerides is oxidized to formaldehyde which reacts with acetylacetone to form a yellow dihydrolutidine derivative absorbing at 405 mμ, correlates well with those given by the ZilversmitVan Handel method.
1,073 citations
TL;DR: A variety of potentially therapeutic growth factors were detected and released from the platelets in significant levels in platelet-rich plasma preparations and may be capable of expediting wound healing in a variety of as yet undetermined specific wound applications.
Abstract: Growth factors released from activated platelets initiate and modulate wound healing in both soft and hard tissues. A recent strategy to promote the wound-healing cascade is to prepare an autologous platelet concentrate suspended in plasma, also known as platelet-rich plasma, that contains growth factors and administer it to wound sites. The purpose of this study was to quantitate platelet number and growth factors released from a prepared platelet concentrate. Whole blood was drawn from 10 healthy patients undergoing cosmetic surgery and concentrated into platelet-rich plasma. Platelet counts on whole blood and platelet-rich plasma were determined using a Cell-Dyn 3200. Platelet-derived growth factor-BB, transforming growth factor-[beta]1, vascular endothelial growth factor, endothelial growth factor, and insulin-like growth factor-1 were measured in the platelet-rich plasma using the enzyme-linked immunosorbent assay method. In addition, platelet activation during the concentration procedure was analyzed by measuring P selectin values in blood serum. An 8-fold increase in platelet concentration was found in the platelet-rich plasma compared with that of whole blood (baseline whole blood, 197 ± 42 × 10 3
1,054 citations