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Boenninghausenia

About: Boenninghausenia is a(n) research topic. Over the lifetime, 46 publication(s) have been published within this topic receiving 382 citation(s).

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Journal ArticleDOI
TL;DR: Bioassay guided fractionation of Boenninghausenia sessilicarpa resulted in the isolation of a new dimeric coumarin glucoside 9′-methoxyl rutarensin and a cytotoxic compound rutamarin, as well as an antivirus component leptodactylone, together with six known coumarins.
Abstract: Bioassay guided fractionation of Boenninghausenia sessilicarpa (Rutaceae) resulted in the isolation of a new dimeric coumarin glucoside 9'-methoxyl rutarensin (1) and a cytotoxic compound rutamarin (4), as well as an antivirus component leptodactylone (8), together with six known coumarins. Their structures were elucidated by 1D- and 2D NMR spectroscopy and ESI-MS analyses, respectively. Rutamarin (4) showed significant inhibitory activities against A-549, Bel-7402, HepG-2 and HCT-8 tumour cell lines with IC50s of 1.318, 2.082, 2.306 and 2.497 microg/ml. In addition, leptodactylone (8) showed potent protective activity on cells infected by SARS-CoV with ratio of 60% at 100 microg/ml.

30 citations

Journal ArticleDOI
TL;DR: From the methanolic extract of the leaves of Boenninghausenia albiflora MEISSNER var.
Abstract: From the methanolic extract of the leaves of Boenninghausenia albiflora MEISSNER var. japonica S. SUZUKI, a new coumarin, named matsukaze-lactone (I), C20H14O6, m.p. 267∼268°, was isolated. Methylation of I with dimethyl sulfate and methanolic alkali gave an acid (IIa), C22H22O8, which was oxidized to an acid (IIIa), C18H18O8. By decarboxylation of IIIa with copper powder, 2, 2', 4, 6'-tetramethoxybiphenyl (V) was obtained. From these results, the structural formula (Ia), (Ib) and (Ic) were proposed for matsukaze-Iactone.

25 citations

Journal ArticleDOI
TL;DR: Various organic and aqueous extracts of aerial part of Boenninghausenia albiflora (Rutaceae) obtained by infusion and maceration were screened for their antimicrobial activity against eight animal and plant pathogenic bacteria using disc diffusion method.
Abstract: Various organic and aqueous extracts of aerial part of Boenninghausenia albiflora (Rutaceae) obtained by infusion and maceration were screened for their antimicrobial activity against eight animal and plant pathogenic bacteria (Bacillus subtilis, Staphylococcus aureus, Erwinia chrysanthemi, Escherichia coli, Proteus vulgaris, Xanthomonas phaseoli, Agrobacterium tumefaciens and Xanthomonas campestris) using disc diffusion method. Out of total 32 tests performed, 27 tests showed positive antibacterial activity at 1000 mg/ml concentration, whereas 15 instances exhibited zone of inhibition ³ 10 mm at same concentration. The activity shown by some of the extracts was found higher than ampicillin (10 mcg) and erythromycin (15 mcg), standard antibiotic used.

25 citations

Journal ArticleDOI
TL;DR: The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth and antiproliferative activity against human gastric adenocarcinoma, human uterus carcinoma, and murine melanoma cells were tested.
Abstract: The MeOH extracts of the ground part and the root of Boenninghausenia japonica NAKAI showed inhibitory activity against tumor cell growth. Fractionation of the extracts has resulted in isolation of 1,3-dihydroxy-4-(2'-hydroxy-3'-hydroxymethyl-3',4'-epoxy-butyl)-N-methylacridone, 1,3-dihydroxy-4-[(Z)-3'-hydroxy-3'-methyl-buten-1'-yl]-N-methylacridone, 3-(1',1'-dimethylallyl)-7-hydroxy-8-methoxy-2H-1-benzopyran-2-one, casegravol, cis-casegravol, and edgeworin in addition to 9 compounds reported from B. japonica and B. albiflora. The isolates from this plant and some related compounds were tested for antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.

21 citations

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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20211
20201
20183
20161
20146
20131