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Showing papers on "Brucine published in 1982"


Journal ArticleDOI
TL;DR: In this article, the electrochemical properties of 1-bromo-2,2,diphenylcyclopropane carboxylic acid, its methyl ester and 1,1-dibromo 2,2-diphexagonalcyclopropanes were investigated in the presence of strongly adsorbed alkaloids: yohimbine, emetine, brucine, strychnine and methylstrychninium cations.

25 citations


Journal ArticleDOI
TL;DR: Studies on the binding spectra of certain alkaloids with rat liver microsomes revealed that brucine, scopolamine and strychnine are type I compounds, whereas boldine, emetine, nicotine, reserpine and sanguinarine show type II binding, while colchicine and solanine failed to produce any measurable binding spectRA.
Abstract: Studies on the binding spectra of certain alkaloids with rat liver microsomes revealed that brucine, scopolamine and strychnine are type I compounds, whereas boldine, emetine, nicotine, reserpine and sanguinarine show type II binding. In contrast, colchicine and solanine failed to produce any measurable binding spectra. In vitro incubation of colchicine, nicotine or scopolamine with microsomal suspensions and NADPH resulted in demethylation of these alkaloids, while the incubation of boldine, brucine, emetine, reserpine, sanguinarine or solanine showed little or no dealkylation reaction. Furthermore, the effect of these alkaloids on the in vitro microsomal metabolism of a drug, benzphetamine, has also been studied.

16 citations


Journal ArticleDOI
TL;DR: A high performance liquid chromatography (HPLC) method was developed for the quantitation of strychnine in urine of children with nonketotic hyperglycinaemia and other developmental disorders treated with the alkaloid and the fast disappearance in vitro from a guinea pig liver preparation was confirmed.
Abstract: A high performance liquid chromatography (HPLC) method was developed for the quantitation of strychnine in urine of children with nonketotic hyperglycinaemia and other developmental disorders treated with the alkaloid. Mobile and stationary phases were polar, i.e. methanol-water-330 g/kg ammonia (volumes, 85 ml + 14.2 ml + 0.8 ml) and LiChrosorb Si-60, 7 microns. Brucine was the internal standard. Extraction was performed by the Extrelut technique. At strychnine nitrate concentrations in urine of 21, 126, and 70 micrograms/l, recovery was 92.1 +/- 8.7, 98.1 +/- 2.7, and 102.5 +/- 2.7%. A child with nonketotic hyperglycinaemia under continued strychnine treatment excreted 1 to 13.6% of the daily dose unmetabolized in urine. The method was also suitable for the estimation of unreacted strychnine in tissue extracts. The fast disappearance in vitro of strychnine from a guinea pig liver preparation was confirmed.

9 citations


Journal ArticleDOI
TL;DR: Optically active (−)- and (+)-2,2′,6,6′-tetrafluorobiphenyl-3,3′-dicarboxylic acids were obtained through brucine salts as mentioned in this paper.
Abstract: Optically active (−)- and (+)-2,2′,6,6′-tetrafluorobiphenyl-3,3′-dicarboxylic acids were obtained through brucine salts. The half-life times for racemization of their dimethyl esters were estimated at various temperatures and the activation energy was calculated to be 25.6 kcal/mol.

7 citations


Journal ArticleDOI
TL;DR: After the frog tongue was adapted for 10 sec to various salts and sugars, the initial phasic component of gustatory neural responses to almost all of quinine hydrochloride, quinines sulfate, and Q-H2SO4 were unchanged and those to brucine and caffeine were enhanced, and that to picric acid was depressed slightly.

6 citations


Patent
24 Feb 1982
TL;DR: In this paper, an improved process for the production of highly active optical isomers of (-) 7 or 8 fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide having the structural formula ##STR1## was presented.
Abstract: The present invention is concerned with an improved process for the production of highly active optical isomers of (-) 7 or 8 fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide having the structural formula ##STR1## in which the fluoro substituent replaces a hydrogen in the 7 or 8 position. The two active isomers represented by formula II are S(-)7-fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide and R(-)8-fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide. It is especially concerned with the resolution of the racemic 7 or 8 fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide by first forming and separating diastereomers of said racemic carboxylic acids by salt formation with brucine or ephedrine followed by crystallization and regeneration of the desired (-) isomers and recycling of the (+) isomer by racemization of the regenerated isomer. The compounds obtained in high yield by this process are highly active prostaglandin antagonists which are useful in treating a variety of conditions such as allergic asthma.

1 citations