Showing papers on "Brucine published in 1997"

After shave treatment composition

Abstract: A topical composition comprising: (a) A mixture of water, glycerin and propylene glycol; (b) Homopolymer of acrylic acid crosslinked with an allyl ether of pentaerythritol, and allyl ether of sucrose, or an allyl ether of propylene. (c) Isopropyl alcohol; (d) Acetylsalicylic acid and ethyl alcohol denatured with t-butyl alcohol and a combination of two or three of the following: brucine (alkaloid), brucine sulfate or quassin; and (e) Polymer of ethylene oxide that conforms to the formula: H(OCH 2 CH 2 )n OH; wherein n has an average value of 8.

Nonenzymatic reduction of brucine N-oxide by the heme group of cytochrome P450.

Abstract: Evidence showing that cytochrome P450-mediated reduction of brucine N-oxide to brucine by rat liver microsomes proceeds nonenzymatically in the presence of both a reduced pyridine nucleotide and FAD is presented. The microsomal N-oxide reduction appears to proceed in two steps: The first step is reduction of FAD by NADPH or NADH either enzymatically or nonenzymatically. The second step is nonenzymatic reduction of the tertiary amine N-oxide by the reduced flavin and is nonenzymatically catalyzed by the heme group of cytochrome P450.

Electrochemistry of Brucine. 2. The Brucine-Based Determination of Nitrate

Abstract: The electrochemical and chemical reactions of brucine following an oxidation step were investigated by cyclic voltammetry, chronocoulometry, bulk electrolysis, visible spectrophotometry, and electrospray mass spectrometry with the goal of better understanding the brucine-based determination of nitrate. The experiments were performed in acidic solution (0.010−7.0 M sulfuric acid) using carbon paste, glassy carbon, and platinum electrodes. Following a two-electron oxidation (Ep = 0.90−1.15 V vs Ag/AgCl), brucine2+ reacts with water to form an aminochrome (brucichrome) plus methanol. Brucichrome undergoes a reversible two-electron reduction (E°‘ = 0.54 V, 0.01−7.0 M sulfuric acid) to form a hydroquinone and also slowly dimerizes. The dimer is also an aminochrome, and it, too, undergoes a reversible two-electron reduction (E°‘ = 0.39 V). The primary evidence for a dimeric final product comes from electrospray mass spectrometry during electrolysis, elemental analysis, and H-NMR on a product isolated from bulk ...

Determation of strychnine and brucine in Strychnos by HPLC

Abstract: This paper describes the determination of strychnine and brucine in the seeds, root, stem and leaves of Strychnos species by HPLC. The analytical column used was ZY110 YNG-C18. The mobile phase was KH2PO4(0.01 mol.L-1)--MeOH(73:27), pH2.5, regulated by 10% H3PO4. Flow rate was 1.0 ml.min-1. The detection wavelength was 264 nm. The linear ranges of strychmine and brucine were 0.18-7.26 micrograms and 0.11-4.32 micrograms, respectively. The recoveries of strychnine and brucine were 98.27% and 98.04%, respectively. The analytical results showed that the contents of strychnine and brucine in samples showed great difference between different species. The contents of strychnine in the seeds of Strychnos wallichiana and S. ignatii were 5.6% and 3.9%, respectively. These results show that the two Strychnos species may be developed as the resources of strychnine.

Seasonal variation of strychnine and brucine in vegetative parts of strychnos nux-vomica

Abstract: Seasonal variations of strychnine and brucine in different vegetative parts of Strychnos nux-vomica were determined by HPLC. Root bark and stem bark are rich in these two alkaloids. Root wood, stem wood, and twigs are poor sources of strychnine and brucine. In the stem bark, stem wood, and leaves, the alkaloids gradually decrease in amount up to December (winter). In the root bark, there is a tendency towards a gradual increase in these alkaloids up to December.

Chemical constituents of Strychnos nitida G. Don

Abstract: Six compounds were isolated from the root and stem of Strychnos nitida for the first time. On the basis of chemical properties and spectral data, the compounds were identified as beta-sitosterol, strychnine, brucine, cantieyine, lignoceric acid and palmitic acid.