Showing papers on "Brucine published in 2000"
TL;DR: In this paper, the brucine Noxide-mediated asymmetric Pauson-Khand reaction has been further investigated and it was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes.
43 citations
TL;DR: A capillary zone electrophoresis method was developed for the separation and determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation.
Abstract: A capillary zone electrophoresis method was developed for the separation and determination of strychnine and brucine in Strychnos nux-vomica L. and its preparation. The factors that could affect the separation were studied, such as the types and concentrations of electrolytes, pH, ionic strength and organic modifier. The optimum running buffer was 20 mmol/L of ammonium acetate containing 0.2 mol/L of glacial acetic acid (pH 3.64). The applied voltage was 25 kV and the wavelength of the UV detector was set at 214 nm. The established method with dopamine hydrochloride as internal standard was linear in the range of 5-100 microg/mL for both strychnine and brucine. The recovery was 102.96% for strychnine and 98.56% for brucine. The extracts of Strychnos nux-vomica and its preparation could be directly injected for analysis.
17 citations
TL;DR: A facile synthesis, separation and characterization of Meulenhoff's free acid (HBB) derived from 1, 1′-biphenyl-2, 2′-diol were described in this paper.
Abstract: A facile synthesis, separation and characterization of Meulenhoff 's free acid (HBB) derived from 1, 1′-biphenyl-2, 2′-diol were described. HBB, prepared by refluxing a mixture of l, l'-biphenyl-2, 2′-dio] and boric acid in benzene for 3 h, reacted with bulky alkaloids (quinine, quinidine, cinchonine, cinchonidine, brucine and strychnine) in equimolar ratio in benzene or chloroform under reflux to give spiro[6, 6]borate complexes in 72–99 % yields. Their IR and 'H NMR spectral characteristics are presented and discussed.
2 citations
TL;DR: In this article, the brucine Noxide-mediated asymmetric Pauson-Khand reaction has been further investigated and it was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes.
Abstract: The brucine N-oxide-mediated asymmetric Pauson–Khand reaction has been further investigated. It was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes. The studies also revealed that when acetone or 1,2-dimethoxyethane is used as the reaction solvent, enhanced levels of enantioselectivity, up to an enantiomeric ratio of 11:89, are achieved.