Showing papers on "Brucine published in 2004"
TL;DR: 1H Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species and the principal component analysis (PCA) showed a clear discrimination between all samples, using the three first components.
84 citations
TL;DR: In this article, the content of strychnine from Strychnos nux-vomica [corrected] seeds was analyzed and compared to processed seeds by the HPLC-ESI/MS method.
41 citations
TL;DR: A sensitive method for the identification and quantitation of the toxic alkaloids strychnine and brucine from postmortem specimens has been established and was applied for the analysis of blood and gastric contents of a 34-year-old female who died after ingestion of a packet of herbal medicine powder containing the seeds of Strychnos nux-vomica L.
Abstract: A sensitive method for the identification and quantitation of the toxic alkaloids strychnine and brucine from postmortem specimens has been established. After solid-phase extraction using Oasis | MCX cartridges the extracts were analyzed by highperformance liquid chromatography with diode.array detection. The limit of detection was 0.5 ng/mL blood for strychnine and brucine, and the limit of quantitation was 5 ng/mL blood for strychnine and brucine. The method was applied for the analysis of blood and gastric contents of a 34-year-old female who died after ingestion of a packet of herbal medicine powder containing the seeds of Strychnos nux-vomica L. Strychnine and brucine were detected in all the samples. The concentration in our case is consistent with that in previous reports.
32 citations
TL;DR: The modified electrode showed an excellent electrocatalytic activity for the redox of brucine and was characterized by using attenuated total reflection-fourier transform infrared and A.C. Impedance to characterize the AMP SAMs/Au.
20 citations
TL;DR: In this paper, the crystal structures of strychninium N-phthaloyl-D-α-alaninate 2 hydrate and brucinium Nphthaloyd-L-αalaninate 0.5 hydrate were obtained as a result of racemic resolution by stereochemically related stryhnine and brucine, respectively.
Abstract: The crystal structures of strychninium N-phthaloyl-D-α-alaninate 2 hydrate (1) and brucinium N-phthaloyl-L-α-alaninate 0.5 hydrate (2) were obtained as a result of racemic resolution by stereochemically related strychnine and brucine, respectively. Comparison of crystal structures of 1 and 2 with previously presented crystal structures of strychnine with N-benzoyl-L- and brucine with N-benzoyl-D-alanine points at the importance of alkaloid self-assemblies in molecular recognition. Simultaneously, various donor/acceptor capabilities of both alanine derivatives control acceptors’ access of resolving agent self-assemblies and therefore racemic resolution.
20 citations
TL;DR: The enantiomeric resolution of (+/-)-ibuprofen into its enantiomers was achieved by TLC on silica gel plate using optically pure (-)-brucine as a chiral selector and acetonitrile-methanol as the solvent system.
Abstract: The enantiomeric resolution of (±)-ibuprofen into its enantiomers was achieved by TLC on silica gel plate using optically pure (−)-brucine as a chiral selector and acetonitrile–methanol (5:1, v/v) as the solvent system. Spots were located in an iodine chamber. The detection limit was 4.9 µg. The effect of concentration of the chiral selector, temperature and pH on resolution has been studied. Copyright © 2004 John Wiley & Sons, Ltd.
17 citations
TL;DR: Crystals of brucine and its 2-propanol solvate dihydrate exhibit similar monolayer sheet packing, whereas crystals of the acetone Solvate adopt a different mode of packing, as brucines pillars.
Abstract: The crystal structures of brucine (2,3-dimethoxystrychnidin-10-one), C23H26N2O4, brucine acetone solvate, C23H26N2O4·C3H6O, and brucine 2-propanol solvate dihydrate, C23H26N2O4·C3H7O·2H2O, have been determined. Crystals of brucine and its 2-propanol solvate dihydrate exhibit similar monolayer sheet packing, whereas crystals of the acetone solvate adopt a different mode of packing, as brucine pillars. The solvent appears to control the brucine self-assembly on the basis of common donor–acceptor properties of the surfaces.
15 citations
TL;DR: In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized as mentioned in this paper, which permits the deracemization of HPPH with Brucine, giving enantiomersically pure (-)-S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)-5-phenylhydandoin].
Abstract: In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized. This permits the deracemization of HPPH in the presence of brucine, giving enantiomerically pure (-)-(S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)-5-phenylhydandoin]. (C) 2004 Elsevier Ltd. All rights reserved.
6 citations
Journal Article•
TL;DR: S, B, SNO and BNO all have the ability to permeate blood brain barrier and were high in brain and spinal marrow.
Abstract: AIM To study the tissue distribution of strychnos nux vomica alkaloids in rats. METHODS Rats were given strychnos nux vomica alkaloids intravenously and strychnine(S), brucine(B), strychnine N oxide(SNO), brucine N oxide(BNO) in every tissue was determined by HPLC timely. RESULTS The concentration of S, B, SNO and BNO were high in brain and spinal marrow. CONCLUSION S, B, SNO and BNO all have the ability to permeate blood brain barrier.
3 citations
Journal Article•
TL;DR: In this paper, the RP-HPLC method was used for the determination of total alkaloids in Semen Strychni and to optimize its extraction conditions by orthogonal design.
Abstract: Objective To establish the RP- HPLC method for the determination of total alkaloids in Semen Strychni and to optimize its extraction conditions by orthogonal design. Methods With strychnine and brucine content as the indexes, ethonal volume, ethonal concentration , pH and extracting time were screened and L9(34) orthogonal test were applied. Results The optimal extraction conditions were as follows: refluxing and extracting with 6- fold 50 % alcohol (pH=5) for 3 times, one hour for each time. Conclusion The optimized condition is the best for the extraction of alkaloids and this increase the availability of Semen Strychni.
1 citations