Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: In this paper , the Strychnine was detected in seven new species of S. usambarensis, including S. camptoneura, S. tchibangensis, and S. tricalyisoides.
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Journal Article•
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Journal Article•
TL;DR: The Brucine-loaded microemulsion promoted the permeation of brucine and showed the sustained and prolonged delivery and may be promising for the transdermal delivery of bru cine.
Abstract: OBJECTIVE To prepare O/W microemulsion formulation containing brucine and investigate its in vitro transdermal delivery ability.METHODS The microemulsion was prepared and characterized using Zetapals Zeta potential/particle size analysis instrument.The permeation flux of brucine was determined in vitro using Franz diffusion cell.The content of brucine was measured by HPLC.RESULTS The average droplet size of microemulsion containing 1% brucine was(48.0±1.7)nm.The permeation rate of(47.36±2.87)μg·cm~(-2)·h~(-1) was showed in vitro.The permeation of the microemulsion was discribed by the Fick's first diffusion law.CONCLUSION The brucine-loaded microemulsion promoted the permeation of brucine and showed the sustained and prolonged delivery.The microeulsion may be promising for the transdermal delivery of brucine
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TL;DR: The oxidation procedure used in the official assay of nux vomica completely destroys brucine with no loss of strychnine and results compare well with chemical assays with a coefficient of variation of about 1 per cent.
Abstract: With oxidised cellulose as a carboxylic cation exchange medium strychnine can be separated from extraneous interfering materials in a pure form for spectrophotometric assay. When brucine is also present a 2-point spectrophotometric procedure is adopted. Results compare well with chemical assays with a coefficient of variation of about 1 per cent. The oxidation procedure used in the official assay of nux vomica completely destroys brucine with no loss of strychnine.
1 citations