Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
Papers published on a yearly basis
Papers
More filters
TL;DR: In this paper, the anti-cervical cancer activity of Brucine against the cervical (ME-180) cells was evaluated and it was found that the anti cervical cancers activity of brucine inhibited the inflammation, cell proliferation and promoted rate of apoptotic cell death ad reduced the mitochondrial potential.
Abstract: Brucine are the main constituents of Strychnos nux-vomica Earlier reports have determined brucine shows anti-inflammatory, analgesic and excellent anti-tumor drug Even though its anticervical cancer cells remains not clearly evaluated So that, we hypothesized the anti-cervical cancer activity of brucine against the cervical (ME-180) cells Brucine inhibited the inflammation, cell proliferation and promoted rate of apoptotic cell death ad reduced the mitochondrial potential, which is evidenced by respective (AO/EB, Rh-123, and PI) staining Furthermore ELISA and real time PCR reaction determined that brucine were down regulated inflammatory (TNF-α, NF-kB, IL-6 & COX-2) cell proliferation (Cyclin D1) and apoptotic marker Bax, caspase-3, PI3K (phosphoinosital 3 kinase), AKT, mTOR (mammalian target of rapamycin) and over expression Bcl-2, associated death promoter These findings were confirmed and finally suggested that brucine inhibited inflammation, cell proliferation and promoted the apoptosis through the down-regulation of PI3K/AKT/mTOR pathway Taken together, these data were exhibited brucine as a good therapeutic agents for the prevention of anticancer cervical cancer drugs
1 citations
Patent•
22 Oct 1981TL;DR: In this paper, the (S)-5-phenyl-2-pentanol hemiphthalate ester was resolved via the resolution of racemic 5phenyl 2 -pentanol via the hemiscalate esters, followed by diastereomer salt formation with (+)-brucine.
Abstract: Resolution of racemic 5-phenyl-2-pentanol via the hemiphthalate ester, followed by diastereomer salt formation with (+)-brucine, separation of the brucine salt of (S)-5-phenyl-2-pentanol hemiphthalate and recovery of the (S)-alcohol therefrom. The (S)-5-phenyl-2-pentanol is a valuable intermediate for organic synthesis.
1 citations
TL;DR: Favorable quantitation has been achieved using papaverine as the internal standard for samples containing both strychnine and brucine, and the rapidity and precision of this method represent an improvement over previous assays.
1 citations
1 citations
Journal Article•
TL;DR: The experiment proved that glycyrrhizic acid may accelerate the elimination of brucine through up-regulate the P-gp's function in the brain of mice and may be the substrate of P- gp in blood-brain barrier.
Abstract: OBJECTIVE To investigate the effects of glycyrrhizic acid on the kinetics of metabolism for toxic dosage of brucine in plasma and brain,and explore a new antidotal pathway for brucine-induced toxicity.METHODS Male KM mice were injected intraperitoneally with normal saline,glycyrrhizic acid and verapamil for 7 days,respectively.In the 8th day,each animal was injected intraperitoneally with brucine.UPLC-MS/MS method and real-time fluorescence quantitative RT-PCR methods were used to determinate the brucine's concentration and the expression of mdr1a,respectively.RESULTS After treatment with glycyrrhizic acid,the AUC0→10h of brain/plasma concentration ratio decreased 37.6% compaered to control group(P0.05).The RT-PCR results revealed that continuesly treated with glycyrrhizic acid could induce the expression of mdr1a mRNA in the brain of mice.The AUC0→10h and the AUC0→10h of brain/plasma concentration ratio increased 30.7%,32.5% respectively by verapamil(P0.05).CONCLUSION The experiment proved that glycyrrhizic acid may accelerate the elimination of brucine through up-regulate the P-gp's function in the brain of mice.Verapamil could reverse the decreased trend of drug disposition in brain,so brucine may be the substrate of P-gp in blood-brain barrier.
1 citations