Brucine

About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.

Composition for 3D printed cartilage bracket, microsphere and preparation method of composition

Abstract: The invention relates to the field of medicine, and discloses composition for a 3D printed cartilage bracket, a microsphere containing the composition and a preparation method of the composition. The composition comprises polylactic-co-glycolic acid, brucine, polyvinyl alcohol, chitosan and optional strychnine. Taking the total weight of the composition as the baseline, the total content of brucine and optional strychnine is 0.1-10 wt%. The composition for the 3D printed cartilage bracket can be taken as raw materials of the 3D printed cartilage bracket and has appropriate degradation speed; degradation products are harmless to human bodies, good biocompatibility is achieved, adhesion and proliferation of cells are facilitated, and cartilage tissue is promoted to form; besides, a slow-release medicine function is achieved, and the composition has no adverse influence on efficacy.

Strychnine-binding proteins in intestinal cells: novel brucine binding site with binding affinities for alkaloids.

Abstract: The purpose of this work was to define the pharmacology of an intestinal epithelial [3H]strychnine binding site. Strychnine, brucine, verapamil and desmethoxyverapamil bind to small intestinal mucosal homogenates with nanomolar affinity at a site not related to the strychnine receptor, which is in the spinal cord. The antidiarrheal agents, fluperamide and loperamide, and several alkaloids have an order of magnitude lower affinity. Agents that bind to cytochrome P450IID6 also displace [3H]strychnine binding, which implies that the binding site may have some properties similar to the catalytic site of this cytochrome P450 enzyme.

[Influence of different processing methods of four alkaloid contents in Strychnos nux-vomica L].

Abstract: The contents of four alkaloids in different processed products of Strychnos nux-vomica hamely, vomicine, icajine, strychnine N-oxide and brucine N-oxide, were determined by TLC-densitometry. The relationship between alkaloid contents and processing methods was studied.

Influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients

Abstract: Objective To study the influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients. Methods The brucine liposomes were separated by Sephadex G-50, and the influence of various factors on the entrapment efficiencies were investigated. Results The entrapment efficiency was enhanced by increased ammonium sulfate concentration, ethanol volume and PC concentration. Conclusion Burcine liposomes prepared by ammonium sulfate transmembrance gradients can get a high entrapment efficiency, the main influencing factors were ammonium sulfate concentration, ethanol volume and PC concentration.