Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: The results of this study suggested that Tm of TSL should be increased to obtain improved drug delivery efficiency to tumor.
34 citations
TL;DR: Efficient encapsulation of brucine into the novel liposomes, their improved stability, and the price of phospholipids indicate that the novelliposomes may act as promising carriers for active alkaloids such as Brucine.
Abstract: Background: Brucine, the major active alkaloid constituent extracted from traditional Chinese herbal medicine Nux vomica, had been found to possess remarkable antitumor, analgesic, and anti-inflammatory activities. In this study, we attempted to encapsulate brucine into liposomes to improve its therapeutic effects. The entrapment efficiency (EE) and the stability of liposomes are two key factors associated with the therapeutic effects of liposomal drugs. We developed a novel liposome-based brucine formulation that was composed of soybean phosphatidylcholine (SPC) and hydrogenated soybean phosphatidylcholine (HSPC). Method: The liposomes with different phospholipid composition were characterized for their EE, vesicle size, drug release profile, and leakage in vitro. Results: The molar ratio of HSPC/SPC = 1:9 was determined as the optimum ratio. Compared with conventional liposomes composed of only SPC or HSPC, EE of the brucine-loaded novel liposomes was increased markedly, especially at high drug/lipid mo...
34 citations
TL;DR: A sensitive method for the identification and quantitation of the toxic alkaloids strychnine and brucine from postmortem specimens has been established and was applied for the analysis of blood and gastric contents of a 34-year-old female who died after ingestion of a packet of herbal medicine powder containing the seeds of Strychnos nux-vomica L.
Abstract: A sensitive method for the identification and quantitation of the toxic alkaloids strychnine and brucine from postmortem specimens has been established. After solid-phase extraction using Oasis | MCX cartridges the extracts were analyzed by highperformance liquid chromatography with diode.array detection. The limit of detection was 0.5 ng/mL blood for strychnine and brucine, and the limit of quantitation was 5 ng/mL blood for strychnine and brucine. The method was applied for the analysis of blood and gastric contents of a 34-year-old female who died after ingestion of a packet of herbal medicine powder containing the seeds of Strychnos nux-vomica L. Strychnine and brucine were detected in all the samples. The concentration in our case is consistent with that in previous reports.
32 citations
TL;DR: No significant difference was found between each monomer and the total strychnos alkaloids on the pharmacokinetic parameters such as Cmax and AUC in comparative pharmacokinetics studies, which suggested that some other alkaloid in the Semen Strychni may decrease the absorption ofStrychnine and brucine in body.
32 citations
TL;DR: The method was successfully applied for the detection of brucine in traditional pharmaceutical formulations and demonstrated by the analysis of the alkaloid in human serum and urine samples exhibiting considerable potential as a diagnostic tool.
32 citations