Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
Papers published on a yearly basis
Papers
More filters
TL;DR: It is demonstrated that expanding the analysis of anhydrate crystal energy landscapes to higher energy structures and calculating the solvent-accessible volume can be used to estimate non-stoichiometric or channel hydrate ( solvate) formation, without explicitly computing the hydrate/solvate crystal energy landscape.
Abstract: Computational methods were used to generate and explore the crystal structure landscapes of the 2 alkaloids strychnine and brucine. The computed structures were analyzed and rationalized by correlating the modeling results to a rich pool of available experimental data. Despite their structural similarity, the 2 compounds show marked differences in the formation of solid forms. For strychnine, only 1 anhydrous form is reported in the literature and 2 new solvates from 1,4-dioxane were detected in the course of this work. In contrast, 22 solid forms are known so far to exist for brucine, comprising 2 anhydrates, 4 hydrates (HyA – HyC and a 5.25-hydrate), 12 solvates (alcohols and acetone), and 4 heterosolvates (mixed solvates with water and alcohols). For strychnine, it is hard to produce any solid form other than the stable anhydrate, while the formation of specific solid state forms of brucine is governed by a complex interplay between temperature and relative humidity/water activity and it is rather a ch...
32 citations
TL;DR: Of the compounds tested, only strychnine, brucine, taurine and (S)-HA-966 were more potent displacers of [3H]strychnines than of glycine binding.
31 citations
TL;DR: In this article, the TLC behaviour, NMR and MS properties of the chlorometho- and bromomethohalides and -picrates of strychnine and brucine are discussed.
31 citations
TL;DR: In this paper, 15 plant alkaloids and related heterocyclic compounds were tested for their ability to quench singlet oxygen, and Brucine and Strychnine were especially efficient quenchers.
31 citations
TL;DR: MTAF might replace NVP and TAF in the clinical application of Chinese medicine to obtain much higher efficacy and significantly increased pharmacological activities when administered by the oral route were obtained with MTAF.
Abstract: The aim of the study was to investigate the possibility of improving the therapeutic efficacy of the total alkaloid fraction (TAF) extracted from processed nux vomica by reducing the strychnine contents. Most strychnine was removed from TAF to obtain the modified total alkaloid fraction (MTAF). The toxicity and pharmacokinetics of TAF and MTAF were further investigated and compared besides their antitumor, analgesic and anti-inflammatory activities. The results showed that the ratios of brucine to strychnine were 1:2.05 and 2.2:1 for TAF and MTAF, respectively, and the toxicity of TAF was about 3.17-fold higher than that of MTAF. Compared to brucine alone, the elimination of brucine was found to be inhibited by other alkaloids in TAF or MTAF except strychnine. Significantly increased pharmacological activities when administered by the oral route were obtained with MTAF in comparison to TAF and nux vomica powder (NVP). In summary, MTAF might replace NVP and TAF in the clinical application of Chinese medicine to obtain much higher efficacy.
31 citations