Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: A selective, simple and efficient method-ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for determination of two toxic alkaloids, namely strychnine and brucine in mice plasma.
23 citations
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TL;DR: Racemic 6,6′-dimethylbiphenyl-2,2′-dicarboxylic acid (1) could be conveniently synthesized and efficiently resolved by the recrystallization of the brucine salts in satisfactory yields.
Abstract: Racemic 6,6′-dimethylbiphenyl-2,2′-dicarboxylic acid (1) could be conveniently synthesized and efficiently resolved by the recrystallization of the brucine salts in satisfactory yields. Each enantiomer, thus obtained, was confirmed to be optically pure from a high-performance liquid chromatographic (HPLC) analysis on an optically active column.
23 citations
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TL;DR: All the results suggest that P-gp prevented brucine from passing through the in vitro BBB model.
22 citations
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TL;DR: Brucine could suppress the migration of the colorectal cancer in vitro and in vivo and the effect was associated with the inhibition of the Wnt/β-catenin signaling pathway.
22 citations
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TL;DR: In this paper, a method for separating cystine from tyrosine has been worked out, by means of the Sullivan method, the value obtained accounting for most of the sulfur present, evidence has been found for the presence of another sulfur compound which gives the Folin-Looney reaction but not the Sullivan reaction.
Abstract: The method of obtaining crystalline insulin by the brucine method has been discussed and various modifications which were resorted to with some preparations have been pointed out. Crystalline insulin obtained by the brucine method has been recrystallized without the use of brucine, retaining its high activity. Insulin has been crystallized directly from crude insulin without the use of brucine. Crystalline insulin has also been obtained without the use of ammonia Cystine and tyrosine have been isolated from hydrolyzed crystalline insulin, proving the presence of these amino acids in the insulin molecule. A new method for separating cystine from tyrosine has been worked out. By means of the Sullivan method the amount of cystine has been estimated, the value obtained accounting for most of the sulfur present. Evidence has been found for the presence of another sulfur compound which gives the Folin-Looney reaction but not the Sullivan reaction. This may be an extremely difficultly hydrolysable dipeptide of cystine or another disulfide compound. The tyrosine content has been determined by the Folin-Looney colorimetric reaction.
22 citations