Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: A 24-year-old male presented with a history of consumption of a decoction made from the bark of the Strychnos nux vomica tree and developed widespread muscle spasms and convulsions, which were promptly treated.
Abstract: Brucine is the predominant alkaloid present in the bark of the tree Strychnos nux vomica and is a weaker alkaloid when compared to strychnine. However, its toxicological property is akin to strychnine. We report a rare case of brucine poisoning complicated by acute renal failure and rhabdomyolysis. A 24-year-old male presented with a history of consumption of a decoction made from the bark of the Strychnos nux vomica tree. Soon after, he developed widespread muscle spasms and convulsions, which were promptly treated. On the fifth day of admission, he developed features of rhabdomyolysis and acute renal failure. Investigations revealed elevated creatine phosphokinase levels and elevated blood urea and serum creatinine. The patient was managed with hemodialysis and recovered gradually. There are many reports of strychnine poisoning producing rhabdomyolysis and renal failure. In this case report, attention is drawn to the fact that brucine, although a weaker alkaloid, can also produce life threatening complications like rhabdomyolysis and acute renal failure.
21 citations
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TL;DR: The results indicated that the CZE method is simple, rapid, reliable, and can be applied to determine strychnos alkaloids in traditional Chinese herbal medicines.
21 citations
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TL;DR: The 1:1 proton transfer Brucinium compounds from the reaction of the alkaloid brucine with 5-nitrosalicylic acid, 3,5-dinitrosaliclic acid and 5-sulfosalicylic acids, namely anhydrous brucinium 5-nissalicylate (1), bruciniam 3, 5-dinitrosalisticylate monohydrate (2), and brucinia 5-Sulfosalicylates trihydrate (3) have been prepared and their crystal structures
Abstract: The 1:1 proton-transfer brucinium compounds from the reaction of the alkaloid brucine with 5-nitrosalicylic acid, 3,5-dinitrosalicylic acid, and 5-sulfosalicylic acid, namely anhydrous brucinium 5-nitrosalicylate (1), brucinium 3,5-dinitrosalicylate monohydrate (2), and brucinium 5-sulfosalicylate trihydrate (3) have been prepared and their crystal structures determined by X-ray crystallography. All structures further demonstrate the selectivity of brucine for meta-substituted benzoic acids and comprise three-dimensional hydrogen-bonded framework polymers. Two of the compounds (1 and 3) have the previously described undulating brucine sheet host-substructures which incorporate interstitially hydrogen-bonded salicylate anion guest species and additionally in 3 the water molecules of solvation. The structure of 2 differs in having a three-centre brucinium–salicylate anion bidentate N+–H···O(carboxyl) hydrogen-bonding association linking the species through interstitial associations involving also the water molecules of solvation. A review of the crystallographic structural literature on strychnine and brucine is also given.
21 citations
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TL;DR: The alkaloids codeine, 7,8-dihydrocodeine, brucine and strychnine, when adsorbed on Pt/silica (EUROPT-1) induce enantioselectivity and enhance the rate of hydrogenation of the carbonyl function in methyl pyruvate and in butane-2,3-dione.
Abstract: The alkaloids codeine, 7,8-dihydrocodeine, brucine and strychnine, when adsorbed on Pt/silica (EUROPT-1) induce enantioselectivity and enhance the rate of hydrogenation of the carbonyl function in methyl pyruvate and in butane-2,3-dione.
21 citations
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TL;DR: The Strychnos alkaloids have been the focal point of considerable synthetic and spectroscopic effort as discussed by the authors, and the 15N chemical shifts and long-range 1H-15N coupling pathways of strychnine, brucine, and holstiine at natural abundance were established using a gradient-enhanced HMQC sequence optimized for the observation of 1H 15N long-term couplings.
21 citations