Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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21 citations
21 citations
TL;DR: It can be concluded that the BLH developed here could represent a safe, effective and promising transdermal formulation for local treatment of analgesic and anti-inflammatory disease.
Abstract: To reduce the toxicity and enhance the therapeutic efficacy of brucine, a traditional Chinese medicine for relieving arthritic and traumatic pain, in this study, a novel brucine-loaded liposomal hydrogel (BLH) formulation, suitable for topical application, was developed. Spherical liposomes composed of lecithin and cholesterol, with brucine, was prepared by a modified ethanol-dripping method. High percentage (over 80%) of encapsulated brucine in liposomes was obtained. Topical liposomal hydrogel formulations were prepared by further incorporation of the prepared liposomes into structured carbopol 940 hydrogels with the concentration of carbopol 1.0%, the ratio of glycerol to carbopol 8:1 and the brucine content 0.1%. The liposomal hydrogel formulations provided an obvious promotion for skin permeation of bruicne while for the free brucine in hydrogels (BH), there was no detectable drug permeation through the skin. The safety evaluation showed that the prepared BLH were no irritation to both the broken and integrity skin. Pharmacodynamic evaluation revealed that the BLH showed a better therapeutic efficacy than that of the BH. So, it can be concluded that the BLH developed here could represent a safe, effective and promising transdermal formulation for local treatment of analgesic and anti-inflammatory disease.
21 citations
TL;DR: The modified electrode showed an excellent electrocatalytic activity for the redox of brucine and was characterized by using attenuated total reflection-fourier transform infrared and A.C. Impedance to characterize the AMP SAMs/Au.
20 citations
TL;DR: In this paper, the crystal structures of strychninium N-phthaloyl-D-α-alaninate 2 hydrate and brucinium Nphthaloyd-L-αalaninate 0.5 hydrate were obtained as a result of racemic resolution by stereochemically related stryhnine and brucine, respectively.
Abstract: The crystal structures of strychninium N-phthaloyl-D-α-alaninate 2 hydrate (1) and brucinium N-phthaloyl-L-α-alaninate 0.5 hydrate (2) were obtained as a result of racemic resolution by stereochemically related strychnine and brucine, respectively. Comparison of crystal structures of 1 and 2 with previously presented crystal structures of strychnine with N-benzoyl-L- and brucine with N-benzoyl-D-alanine points at the importance of alkaloid self-assemblies in molecular recognition. Simultaneously, various donor/acceptor capabilities of both alanine derivatives control acceptors’ access of resolving agent self-assemblies and therefore racemic resolution.
20 citations