Brucine

About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.

Phase diagram of the cholesteric lyotropic mesophase potassium laurate-n-decanol-water-d2-brucine sulfate ferrofluid

Abstract: A surface of the phase diagram of the cholesteric lyotropic liquid crystal potassium laurate/1-decanol/D/sub 2/O/brucine sulfate heptahydrate/ferrofluid is studied by optical microscopy and X-ray diffraction as a function of the temperature and the relative molar concentration of brucine. The cholesteric pitches as a function of the brucine content are shown to have two independent behaviors for low and high brucine concentration. The brucine doping and its influence in favoring the cholesteric discotic phase formation are discussed in terms of the brucine packing at the electric double layer and its influence on the orientational fluctuations.

In vitro metabolism study of Strychnos alkaloids using high‐performance liquid chromatography combined with hybrid ion trap/time‐of‐flight mass spectrometry

Abstract: In this report, the in vitro metabolism of Strychnos alkaloids was investigated using liquid chromatography/high-resolution mass spectrometry for the first time. Strychnine and brucine were selected as model compounds to determine the universal biotransformations of the Strychnos alkaloids in rat liver microsomes. The incubation mixtures were separated by a bidentate-C18 column, and then analyzed by on-line ion trap/time-of-flight mass spectrometry. With the assistance of mass defect filtering technique, full-scan accurate mass datasets were processed for the discovery of the related metabolites. The structural elucidations of these metabolites were achieved by comparing the changes in accurate molecular masses, calculating chemical component using Formula Predictor software and defining sites of biotransformation based upon accurate MS(n) spectral information. As a result, 31 metabolites were identified, of which 26 metabolites were reported for the first time. These biotransformations included hydroxylation, N-oxidation, epoxidation, methylation, dehydrogenation, de-methoxylation, O-demethylation, as well as hydrolysis reactions.

Rapid separation of strychnine and brucine on a dynamically modified poly(dimethylsiloxane) microchip followed by electrochemical detection

Abstract: A method has been developed for rapidly separating and detecting strychnine and brucine using a poly(dimethysiloxane) (PDMS) microchip and electrochemical (EC) detection. PDMS microchannels dynamically modified by Brij35 are shown to be more efficient than native ones. The two analytes are well separated within 90 s in 70 mmol/L acetate buffer (pH 5.5) containing 0.01% (v/v) Brij35. Detection limits were found to be 1.0 μmol/L for strychnine and 0.2 μmol/L for brucine at S/N=3. The method was used to determine trace strychnine and brucine in rat serum, and the results obtained correlate well with those obtained via high-performance liquid chromatography (HPLC).

Synthesis of the α-hydroxy-analogues of S-benzylcysteine and cysteine

Abstract: β-Chlorolactic acid was condensed with toluene-α-thiol to give 2-hydroxy-3-benzylthiopropanoic acid. The optical isomers were prepared by resolution with brucine and quinine. Removal of benzyl groups yielded (+)- and (–)-2-hydroxy-3-mercaptopropanoic acid. Desulphurization with Raney nickel gave (+)- and (–)-lactic acid. Configuration and optical purity of all isomers have been determined.

Sequential injection determination of chromium(VI) by transient oxidation of brucine with spectrophotometric detection and in-line dilution

Abstract: A sequential injection method for the determination of chromium(VI) in residual waters from electroplating baths and steels is proposed. The method is based on monitoring the absorbance at 525 nm due to an aminochrome intermediate compound resulting from oxidation of the alkaloid brucine. The intermediate brucichrome is unstable so that its analytical use is only possible in closed flowing systems where the precise and reproducible control of time and mixing is possible. The method gave a linear calibration curve from 0.2 to 2 mg l–1 Cr(VI) and a detection limit of 0.045 mg l–1 Cr(VI). A sampling frequency of 120 h–1 is possible. Industrial samples from electroplating baths and residual washing waters were analyzed, and in this case a sequential injection in line dilution was performed, permitting real time determination of samples with Cr(VI) concentrations up to 100 mg l–1 with a sampling frequency of 80 h–1.