Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: Brucine N -oxide reduction proceeds via two routes in liver cytosol and blood; one is enzymatic reduction by aldehyde oxidase; the other is non-enzymatic Reduction catalysed by the haem group of catalase in the presence of reduced flavin.
Abstract: 1. Brucine N -oxide was reduced by aldehyde oxidase in rabbit liver cytosol in the presence of an electron donor, 2-hydroxypyrimidine, under anaerobic conditions. The flavoprotein purified from rabbit liver exhibited significant reductase activity in the presence of electron donors. 2. Brucine N -oxide was also reduced by rabbit liver cytosol and blood in the presence of both a reduced pyridine nucleotide and FAD under anaerobic conditions. The N -oxide reductase activities were inhibited by carbon monoxide and air. However, these activities were not abolished when liver cytosol and blood were boiled. Rabbit erythrocytes exhibited the reductase activity, but not plasma. 3. When liver cytosol or blood was separated by DEAE-cellulose column chromatography, the fractions with the reducing activity in the presence of both NADH and FAD also showed catalase activity. 4. Catalase catalysed the brucine N -oxide reduction in the presence of both NAD(P)H and FAD. Hematin also exhibited the reductase activity in the...
13 citations
TL;DR: In this paper, a solution of a cyanohydrin and brucine in methanol was kept at room temperature, and one optically active isomer of the cyanhydrin was obtained as Brucine complex in a yield of more than 50%.
Abstract: When a solution of a cyanohydrin and brucine in methanol was kept at room temperature, one optically active isomer of the cyanohydrin was obtained as brucine complex in a yield of more than 50%.
13 citations
TL;DR: The seeds of a south Indian sample of Strychnos wallichiana Steud, previously analysed by Short (1924) under the name S. cinnamomifolia Thwaites, have now been shown to contain a new base 4‐hydroxy‐3‐methoxystrychnine (I) as the major alkaloidal constituent.
Abstract: The seeds of a south Indian sample of Strychnos wallichiana Steud. ex DC., previously analysed by Short (1924) under the name S. cinnamomifolia Thwaites and thought to contain mostly brucine with a little strychnine, have now been shown to contain a new base 4-hydroxy-3-methoxystrychnine (I) as the major alkaloidal constituent. Smaller amounts of strychnine, 4-hydroxystrychnine, brucine, vomicine, 4-hydroxy-3-methoxy-N-methyl-sec.-pseudostrychnine (II), and nova-cine and possibly also α-colubrine are present.
13 citations
TL;DR: In this article, a method for the separation of all the components of a complex mixture of acids or bases by counter-current distribution with progressive variation of the pH was proposed, and the function that controls the double distribution and dissociation equilibrium in the case of a weak base was investigated.
13 citations
01 Sep 1976
TL;DR: In the stem bark of Strychnos dolichothyrsa Gilg ex Onochie et Hepper (Loganiaceae) the following alkaloids were found: bisnor-dihydrotoxiferine, bisnor
Abstract: In the stem bark of Strychnos dolichothyrsa Gilg ex Onochie et Hepper (Loganiaceae) the following alkaloids were found: bisnor-dihydrotoxiferine, bisnor-C-curarine, bisnor-dihydrotoxiferine N-oxide and bisnor-dihydrotoxiferine di-N-oxide. Tentatively, two alkaloids were identified as bisnor-C-alkaloid D and 18-deoxy Wieland-Gumlich aldehyde. Bisnor-dihydrotoxiferine seems to give dichlorometho compounds and N-oxides easily, analogous with strychnine and brucine.
13 citations