Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: This article showed that Nα, Nδ-diphthaloyl-4-oxalysine has a negative Cotton-effect from which they conclude that this stereoisomer possesses the D-configuration.
Abstract: Both enantiomorphs have been isolated from racemic Nα, Nδ-diphthaloyl-4-oxalysine in optically pure form via brucine salts and converted into (+)-and (-)-4-oxalysine by acid hydrolysis.
(-)-4-Oxalysine has a negative Cotton-effect from which we conclude that this stereoisomer possesses the D-configuration. This conclusion is corroborated by the formation of a quasi-racemic compound between (+)-Nα, Nδ-diphthaloyl-4-oxalysine, stereochemically corresponding to (-)-oxalysine, and Nα, Nδ-diphthaloyl-L-4-thialysine.
6 citations
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6 citations
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TL;DR: In this paper, a method for the chromatographic determination of strychnine and brucine in various herbal/ayurvedic sample preparations, homeopathic medicines, containing Nux-vomica, seeds of Nux vomica as well as in spiked serum and real urine samples are described.
Abstract: Nux-vomica is a tropical plant that contains two ergot alkaloids i.e. strychnine and brucine which have pharmaceutical and toxic properties. In some places, for example in India, Nux-vomica is used in ayurvedic preparations in homeopathic medicine. As both compounds are toxic monitoring is required. In this work a method for the chromatographic determination of strychnine and brucine in various herbal/ayurvedic sample preparations, homeopathic medicines, containing Nux-vomica, seeds of Nux-vomica as well as in spiked serum and real urine samples are described. The method involves a direct injection micellar liquid chromatography technique that was optimised under ICH guidelines. Optimum conditions are a mobile phase composed by 0.10 M SDS-pentanol 4% (v/v)-NaH2PO4 buffered at pH 3 with UV detection at 258 nm, flow rate of 1 mL min−1, and temperature 25 °C. Under these conditions strychnine and brucine were analyzed in 15 and 11 min, respectively. Validation studies using ICH guidelines were performed to show that the proposed method was linear (r2 > 0.9997), with LODs (0.18 and 0.09) and LOQs (0.69 and 0.35), for strycnine and brucine, respectively. Repeatability intra- and inter-day was below of 2.50. The developed method can be useful for analyzing strychnine and brucine for quality control and other related forensic and clinical cases.
6 citations
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6 citations
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TL;DR: In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized as mentioned in this paper, which permits the deracemization of HPPH with Brucine, giving enantiomersically pure (-)-S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)-5-phenylhydandoin].
Abstract: In the presence of 10% NaOH in boiling MeOH enantiomerically enriched HPPH is racemized. This permits the deracemization of HPPH in the presence of brucine, giving enantiomerically pure (-)-(S)-HPPH [(-)-(S)-5-(4-hydroxyphenyl)-5-phenylhydandoin]. (C) 2004 Elsevier Ltd. All rights reserved.
6 citations