Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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TL;DR: The structure of the title compound C23H27N2O4+. C8 H5O4. 3H2O, has been determined at 130 K as discussed by the authors, where hydrogenisophthalate anions and the water molecules associate through extensive hydrogen-bonding interactions, including those with the common undulating brucinium cation layer substructures, forming a three-dimensional framework structure.
Abstract: The structure of the title compound C23H27N2O4+ . C8 H5O4 . 3H2O, has been determined at 130 K. The hydrogenisophthalate anions and the water molecules (one of which is disordered over two approximately equal sites) associate through extensive hydrogen-bonding interactions, including those with the common undulating brucinium cation layer substructures, forming a three-dimensional framework structure.
4 citations
TL;DR: Alcohol prolan shows the electrokinetic behavior of a single chemical individual and the isoelectric point is more acid than pH 3.5.
Abstract: SummaryAlcohol prolan shows the electrokinetic behavior of a single chemical individual. The isoelectric point is more acid than pH 3.5. Brucine prolan behaves as a mixture. The physiological activity of prolan is attributed to a grouping which may survive chemical treatment drastic enough to alter the protein-like carrier.
4 citations
TL;DR: Brucine exerts effects on bone metabolism in multiple myeloma through the regulation of osteoclasts by osteoblasts throughThe effects of brucine on bone digestion and metabolism are explored and compared with bortezomib regarding the effects on MM in vitro.
Abstract: The aim of this study was to explore the effects of brucine on bone metabolism in multiple myeloma (MM) and to compare brucine and bortezomib regarding the effects on MM in vitro. The half maximal inhibitory concentration (IC50) values of brucine and bortezomib in the MM cell line U266 were detected by MTT assay. In addition, the expression of alkaline phosphatase (ALP), osteocalcin (OC), osteoprotegerin (OPG) and osteoprotegerin ligand (also termed receptor activator of nuclear factor κB ligand) (RANKL) at mRNA levels were measured by RT-PCR. IC50 of bortezomib in the U266 cell line at 48 h was 22.4 nmol/l, and that of brucine was 0.16 nmol/l. Compared with osteoblasts incubated with MM cell supernatant alone, the mRNA levels of ALP, OC and OPG in osteoblasts co-treated with brucine and MM cell supernatant were higher (p<0.05), while the mRNA expression of RANKL was lower, and the ranges of the changes were all larger than those of the group treated with bortezomib (P<0.05). Brucine exerts effects on bone metabolism in multiple myeloma through the regulation of osteoclasts by osteoblasts.
4 citations
4 citations
TL;DR: Results indicate that the reaction of nitrate ion with brucine and 3-methyl-2-benzothiazolinone hydrazone hydrochloride in sulfuric acid medium to yield a violet-colored product which is stable for over two days is highly sensitive.
Abstract: A modified and highly sensitive spectrophotometric method for the determination of nitrate in trace quantities in environmental samples is described. The method is based on the reaction of nitrate ion with brucine and 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) in sulfuric acid medium to yield a violet-colored product which is stable for over two days. The optimum photometric range for the determination of nitrate is 0.04-0.16 microg cm(-3) and the Sandell's sensitivity being 0.000279 microg cm(-2). The proposed method is applied to various water samples and the results indicate that the reaction is highly sensitive than the original brucine method.
4 citations