Brucine

About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.

[Influence of processing methods on alkaloid, toxicity and effect of Strychnos nux-vomica L].

Abstract: Determination has been made on the contents of strychnine, brucine and ephedrin in different processed products of Strychnos nux-vomica. The acute toxicity, analgesic and antiphlogistic actions of these products have also been detected. The result shows that the product processed with Ephedra sinica can reduce toxicity and promote curative effect. Among the different processing methods the preparation with Ephedra and Liqorice root and the preparation with Ephedra and alcohol appear better and thus useful in practical application.

Brucine, part 1: Electrochemistry of brucine

Abstract: Cyclic voltammetry and chronocoulometry were used to study the electrochemistry of brucine. The oxidation of brucine 0.9 V versus a saturated calomel electrode at a carbon paste electrode produces a compound that undergoes reversible electrochemical behavior at Eo′ = 0.47 V. The product formed on the oxidation of brucine undergoes a slow chemical reaction to produce a compound that shows reversible behavior at Eo′ = 0.27 V. The hexadecane content of the carbon paste plays an important role in the observed behavior. Electrodes with low hexadecane did show oxidation of brucine, but irreversible waves occurred at Eo′ = 0.47 and 0.27 V. These features were also displayed by a platinum electrode. Calcium oxalate incorporated into the carbon paste catalyzes the oxidation of brucine. Chronocoulometry was used to estimate the heterogenous rate constant for the oxidation of brucine at calcium oxalate-modified and unmodified electrodes. The values found were 21.4 × 10−3 cm/s for the modified electrode and 6.1 × 10−3 cm/s for the unmodified electrode. Preliminary results on the use of brucine as a reagent for the determination of nitrate are given.

Anti-tumor effect of brucine

Abstract: OBJECTIVE:To review advances of the anti-tumor effect and the involved mechanisms of brucineMETHODS:The related literature of anti-tumor effect of brucine was retrieved in PubMed and cnki from 1992-01-2012-01Key words were brucine and anti-tumor effect,and 126articals were obtainedThe included criteria:1) Anti-tumor effect of brucine2) Anti-tumor mechanism of of brucineThirty documents were reviewed according to the inclusion criteriaRESULTS:Brucine has antitumor effect in vitro and in vivoThe current studies found that brucine has growth inhibitory effects on hepatoma cell line SMMC 7221,Heps and H22Moreover,brucine can inhibit human breast cell line MDA-MB-231and MCF-7,human chronic myeloid leukemia cell line K562cells and multiple myeloma(MM) cell line U266,etcThe anti-tumor mechanism of brucine involves apoptosis,anti-angiogenesis,decreasing VEGF and TNF-αexpression,increasing IL-12expression and reversal of tumor cell multidrug resistanceCONCLUSION:Brucine has antitumor effect on many kinds of tumor cells both in vitro and in vivo by various mechanisms