Brucine

About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.

Effect of γ-aminobutyric acid upon brucine convulsions

Abstract: Bhagat, B., Gordon, E. & Kopin, I. J. (1965). J. Pharmacol. In the press. Burn, J. H. &Rand, M. J. (1958). J. Physiol., 144, 314-336. Crout, J. R., Muskus, A. J. & Trendelenburg, V. (1962), Zbid., 18, 600-611. Kopin, I. J. & Gordon, E. K. (1962). J. Pharrnacol., 138, 351-358. Shore, P. A. & O h , J. S. (1958). Zbid., 122, 295-300. Spector, S . , Sjoerdsma, A. & Udenfriend, S. (1964). Pharmacologist, 6 , 62. Trendelenburg, U. (1961), J . Pharrnacol., 136, 8-15. Arch int. Pharmacodyn., 147, 26-35. Pharmacologist, 6, 206.

Correlation of Pharmacological action of Ignatia Amara Homoeopathic Mother tincture to its active principles employing High Performance Thin Layer Chromatography

Abstract: Ignatia contains a considerable amount of strychnine and Brucine, more indeed in proportion than Nux Vomica. It is these alkaloids that it owes much of its energy. In poisonous quantities, Ignatia causes tetanic spasms while in small doses, it cures the same symptoms. Ignatia exalts the impressionability of the incident nerves all over the body. It causes reflex excitation- twitching, constrictions, and spasms. This action is not deep and long lasting. Alternate set of symptoms are numbness, torpor. Ignatia acts specially on the Medulla oblongata and spinal nervous system giving rise to these tetanic convulsions. The entire nervous system gets affected making the system sensitive so much that there is intense acuteness of the nerves of sensation and of special senses and increased susceptibility of external impressions, mental and physical. If we were to correlate this with the pharmacological action of Strychnine and Brucine, all the actions of Ignatia can aptly be assigned to the pharmacological action of these two active principles. This can be verified by High Performance Thin Layer Chromatography which would help to segregate and identify the constituents present in the Ignatia Amra mother tincture and correlate their action with the pharmacological action of Ignatia Amra. Materials and Methods: Standard Ignatia Amara mother tincture was tested for its alkaloid markers and its correlation with the pharmacological action was studied. High Performance Thin Layer Chromatography was used for qualitative analysis if Ignatia Amra homoeopathic mother tincture. TLC Aluminium sheets with silica gel 60 F253 pre-coated layer (20cm x 10cm), thickness-0.2mm, no. of tracks-18, band length-6mm constituted the stationary phase. Chloroform: Methanol (9.5:0.5) constituted the mobile phase. The plate was developed in developing chamber and observed under U.V. Light. Results: Rf. Values of the Ignatia Amara homoeopathic mother tincture were observed at 0.67 and 0.70 which corresponds to the Rf. Value of Brucine which is 0.69. Superimposed UV Spectra of brucine standard shows y-max at 306nm whereas superimposed UV Spectra of strychnine standard shows y-max at 259nm which matches with the y-max shown by Ignatia Amra mother tincture one at 260nm and other at 306nm. Conclusion: Thus, it is evident from the chromatogram that Ignatia Amara homoeopathic Mother tincture contains both Brucine and Strychnine which is supported by evidence in the source books. This helps correlate the action of Ignatia Amara homoeopathic mother tincture with its active principles namely Brucine and Strychnine.

Brucine‐Derived Amino Alcohol Catalyzed Asymmetric Henry Reaction: An Orthogonal Enantioselectivity Approach.

Abstract: A new approach to both enantioenriched Henry products is developed by use of different molecularities of metal−ligand complexes generated from Cu(I) and Zn(II) metals with readily available chiral amino alcohol 1.

Detoxification mechanisms of a combination of Semen Strychni and Radix Glycyrrhizae: A comparative analyses of differences in toxicokinetics and tissue distribution after oral administration of Semen Strychni-Radix Glycyrrhizae decoction.

Abstract: To evaluate the detoxification effect of a combination of Radix Glycyrrhizae (GU) and Semen Strychni (SN) from toxicokinetics and drug tissue distribution perspectives, decoctions of processed SN and codecoction of SN and GU (SGN) were prepared, and an HPLC-ESI-MS/MS method was developed to monitor the severe exposure level in one-month toxicokinetics and tissue distribution experiments to detect brucine and strychnine in rats. The toxicokinetic characteristics and tissue distribution before and after the addition of GU were analyzed. The method was successfully applied to evaluate the toxicokinetics and tissue distribution before and after the combination of SN and GU. The results show that GU decreased the blood concentration of toxic components in SN, and a double peak was observed in the drug time curve. The results of tissue distribution show that a combination of GU and SN significantly decreased the accumulation of toxic substances in metabolic organs and accelerated the clearance of toxic substances in the brain. These results provide a reference for the toxicity reduction mechanism of GU combined with SN.