Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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Journal Article•
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Journal Article•
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TL;DR: In this paper, an aldose reductase inhibitor with potential utility in the treatment of chronic diabetic complications, trritiated sorbinil was prepared by reductive dehalogenation of the 8-chloro substituted analog with 3H2.
Abstract: The syntheses of 3H- and 14C-label led S-(+)-6-fluoro-2,3-dihydrospiro-[4H-1-benzopyran-4,4′-imidazolidin]-2′,5′-dione (sorbinil, CP-45,634), an aldose reductase inhibitor with potential utility in the treatment of chronic diabetic complications, are described. Tritiated sorbinil was prepared by a reductive dehalogenation of the 8-chloro substituted analog with 3H2. 14C-labelled CP-45,634 was prepared using a Bucherer-Bergs synthesis of the racemic hydanto in beginning with 2,3-dihydro-6-fluoro-4H-1-benzopyran-4-one and 14C-potassium cyanide, followed by brucine resolution to isolate the pharmacologically active S-(+)-enantiomer.
2 citations
TL;DR: Brucin and Strychnin ergeben Vergrösserung der spontanen Potentiale aus Telencephalus-Gewebe (in vitro) und die Reaktion des Explants auf Pharmaka stimmt mit derjenigen des intakten Zentralnerven systems, der Nervenzellen und ihrer Axone überein.
Abstract: Brucin and Strychnin ergeben Vergrosserung der spontanen Potentiale aus Telencephalus-Gewebe (in vitro). Die Potentialzunahme nimmt bei Zusatz von Natriumphenobarbital ab und wird durch Betaubungsmittel aufgehoben. Die Reaktion des Explants auf Pharmaka stimmt mit derjenigen des intakten Zentralnervensystems, der Nervenzellen und ihrer Axone uberein.
2 citations