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Brucine

About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.


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Journal ArticleDOI
TL;DR: In this paper, the antibacterial activity of Strychnos nux vomica leaves showed inhibitory effects on selective bacteria which could be used to control these microbes, but Salmonella typhimurium survived the inhibition.
Abstract: Strychnos nux vomica is a non edible tree with a strong content of two poisonous alkaloids, strychnine and brucine. Qualitative phytochemical analysis and antimicrobial activity of the aqueous methanolic extract of its leaves were studied. Alkaloids, triterpenes, oils & fats, phenol, tannins and flavonoids were present. Escherichia coli Enterobacter, Staphylococcus aureus, and Pseudomonas showed susceptibility but Salmonella typhimurium survived the inhibition. Minimal inhibitory concentration of the extract for E. coliafter an overnight incubation was found to be 0.25 mg. In the present study the antibacterial activity of Strychnos nux vomica leaves showed inhibitory effects on selective bacteria which could be used to control these microbes.

2 citations

Patent
28 Feb 1989
TL;DR: In this paper, a process for resolving (±)-cis-1-ethyl-1, 3, 4, 9-tetrahydro-4-(phenylmethyl)pyrano[3, 4-b]indole-1acetic acid (pemedolac) usinig brucine to obtain the corresponding (1S, 4R)-eutomer is useful as an analgesic
Abstract: This invention relates to a process for resolving (±)-cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole-1-acetic acid (pemedolac) usinig brucine to obtain the corresponding (1S,4R)-eutomer Said eutomer is useful as an analgesic

2 citations

01 Jan 2012
TL;DR: A B ST R A C T Strychnos potatorum (Clearing nut) is an important medicinal plant used in the traditional and folk medicine for treating several aliments including microbial infections, diarrhoea and diabetes.
Abstract: A B ST R A C T Strychnos potatorum (Clearing nut), an important medicinal plant used in the traditional and folk medicine for treating several aliments including microbial infections, diarrhoea and diabetes. Some of its pharmacognostic studies such as fluorescent, organoleptic, ash and mineral contents of root, stem bark and seed (both collected and market) , and GC- alkaloid profiles of seed have been investigated. Considerable colour variations in the fluorescent behaviour of raw drugs were observed. The highest yields were obtained for the aqueous extracts followed by ethanol, petroleum ether and chloroform extracts. The colour of the extracts thus obtained have from ivory to dark brown and bitter to pungent bitter in taste. Higher values of the total ash and insoluble acid contents were recorded for the stem bark, followed by root and seed samples. Considerable amounts of iron and copper found in all parts of the plant. However, lead, a toxic element was found in trace amount in the market seed sample. Further, the GC-alkaloid profiles of seed samples have shown significant variation in terms of percent area of peaks. Furthermore, the co-TLC study has revealed the absence of strychnine and brucine from the seed sample.

2 citations

Journal ArticleDOI
TL;DR: Wang et al. as mentioned in this paper investigated the neurotoxicity and mechanism of brucine and showed that Brucine significantly induced Neuro-2a cells and primary astrocyte death, as evidenced by MTT assay and LDH release.
Abstract: Brucine, a weak alkaline indole alkaloid, is one of the main bioactive and toxic constituents of Strychnos nux-vomica L., which exerts multiple pharmacological activities, such as anti-tumor, anti-inflammatory, and analgesic effect. However, its potential toxic effects limited its clinical application, especially central nervous system toxicity. The present study was designed to investigate the neurotoxicity and mechanism of brucine. Our results showed that brucine significantly induced Neuro-2a cells and primary astrocyte death, as evidenced by MTT assay and LDH release. Moreover, transcriptome analysis indicated that PPAR/NF-κB and apoptosis signaling pathways were involved in the brucine-induced cytotoxicity in Neuro-2a cells. Subsequently, in fact, brucine evidently inhibited PPARγ and promoted phosphorylation of NF-κB. Furthermore, PPARγ inhibitor aggravated the neurotoxicity, while NF-κB inhibitor substantially reversed brucine-induced neurotoxicity. Moreover, brucine also significantly induced neuronal apoptosis and triggered increase in ratio of Bax/Bcl-2 and level of cleaved caspase 3, as well as its activity as evidenced by TUNEL staining and Western blot. Furthermore, molecular docking analysis predicted that brucine directly bound to caspase 3. Intriguingly, a caspase 3 inhibitor (Z-DEVE-FMK) largely abolished the neurotoxicity of brucine. Our results reveal that brucine-induced neurotoxicity via activation of PPARγ/NF-κB/caspase 3-dependent apoptosis pathway. These findings will provide a novel strategy against brucine-induced neurotoxicity.

2 citations

Journal ArticleDOI
TL;DR: In this article, the IR spectrum of Brucine with the spectra of the complexes implies that the transition metals prefer to form complexes with oxygen, except (partially) for nickel, or with the π-electron cloud of the double bond in the case of palladium.

2 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20235
202224
202117
20208
201912
201812