Topic
Brucine
About: Brucine is a research topic. Over the lifetime, 586 publications have been published within this topic receiving 6866 citations. The topic is also known as: 10,11-dimethoxy strychnine.
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Journal Article•
TL;DR: Brucine and strychnine have medium capacity in binding to plasma protein, and in comparison with the single component of the same concentration, the protein binding rate of brucine in total alkaloids shows little difference, while there seems to be an obvious decrease for stRYchnine.
Abstract: Objective To determine the plasma protein binding rates of brucine and strychnine in total alkaloids from the seed of Strychnou nux-vomica, and make comparison with the single components at the same concentration. Method Ultrafiltration was employed to determine the rat the plasma protein binding rate of the alkaloids from the seed of S. nux-vomica. The plasma concentrations were measured by RP-HPLC. Result The protein binding rates of brucine were (65.60 3.01)%, (68.20 +/- 7.80)%, (59.58 +/- 3.78)% when the plasma concentrations was 0.520, 1.300, 2.600 mg x L(-1), respectively. The protein binding rates of strychnine was (66.17 +/- 6.36)%, (67.10 +/- 2.52)%, (57.21 +/- 0.79)% when the plasma concentrations were 0.936, 2.340, 4.680 mg x L(-1) respectively. As to the total alkaloids from the seed of S. nux-vomica, The protein binding rate of brucine was (62.19 +/- 2.45)%, (69.55 +/- 5.84)%, (61.76 +/- 3.68)% when the plasma concentrations were 0.519, 1.288, 2.607 mg x L(-1), respectively. And the protein binding rates of strychnine were (54.79 +/- 3.55)%, (57.13 +/- 4.49)%, (59.31 +/- 3.65)% when the plasma concentrations were 0.940, 2.338, 4.674 mg x L(-1), respectively. Conclusion Brucine and strychnine have medium capacity in binding to plasma protein. In comparison with the single component of the same concentration, the protein binding rate of brucine in total alkaloids shows little difference, while there seems to be an obvious decrease for strychnine.
2 citations
TL;DR: In this article , the main components in different phase states were analyzed via reliable UFLC-Q-TOF-MS high-resolution mass spectrometry, and the established UPLC-qqq-MS/MS method is accurate and reliable with a good linearity (R2 > 0.99) in the respective concentration range, satisfying the quantitative requirements.
2 citations
TL;DR: A novel indolomonoterpenic alkaloid, 4-hydroxy-19-methyl-16,19-seco-12,24-sec-strychnidine-10,16-dione (1), together with three known compounds 2-4 (vomicine, strychnine, and brucine), have been isolated from processed Strychnos nux-vomica as discussed by the authors.
Abstract: A novel indolomonoterpenic alkaloid, 4-hydroxy-19-methyl-16,19-seco-12,24-seco-strychnidine-10,16-dione (1), together with three known compounds 2–4 (vomicine, strychnine, and brucine), have been isolated from processed Strychnos nux-vomica. Its structure was determined by detailed spectral analysis (1H NMR,13C NMR, 1H–1H COSY, HMBC, and HR-ESI-MS).
2 citations
TL;DR: In this article, the Weisz ring colorimetry method was applied to the microscale determination of alkaloids, and the following substances were determined: nicotine, atropine, cinchonine, quinine, narcotine, codeine, aconitine, strychnine, and brucine.
Abstract: The Weisz ring colorimetry method has been applied to the microscale determination of alkaloids. The following substances were determined: nicotine, atropine, cinchonine, quinine, narcotine, morphine, codeine, aconitine, strychnine, and brucine. The errors obtained amounted, on an average, to about 3%, and the determinations were performed with 10–50 μg of the alkaloids investigated.
2 citations
Journal Article•
TL;DR: In this paper, an objective HPLC method was used to determine strychnine and brucine in the decoction of Semen Strychni and its processed products of Jiangxi methods and innovated methods.
Abstract: Objective HPLC method was used to determine strychnine and brucine in the decoction of Semen Strychni and its processed products of Jiangxi methods and innovated methods.Methods SiO2 was used as the stationary phase,n-hexane∶dichloromethane∶methanol∶ammonia(47.5∶47.5∶5∶0.35) as the mobile phase,with detection wavelength at 254 nm.Result The contents of strychnine and brucine in the processed products of Jiangxi methods and innovated methods were low.The content of that in acetic acid-soaked product scalded with hot sand was the lowest.Conclusion Semen Strychni and its processed products of Jiangxi methods and innovated methods can lower the toxicity and improve the safety of clinical use.
1 citations