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Butanol

About: Butanol is a(n) research topic. Over the lifetime, 6317 publication(s) have been published within this topic receiving 139889 citation(s). The topic is also known as: butyl alcohol.

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Journal ArticleDOI
Shota Atsumi1, Taizo Hanai, James C. Liao1Institutions (1)
03 Jan 2008-Nature
TL;DR: This strategy uses the host’s highly active amino acid biosynthetic pathway and diverts its 2-keto acid intermediates for alcohol synthesis to achieve high-yield, high-specificity production of isobutanol from glucose.

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Abstract: Global energy and environmental problems have stimulated increased efforts towards synthesizing biofuels from renewable resources. Compared to the traditional biofuel, ethanol, higher alcohols offer advantages as gasoline substitutes because of their higher energy density and lower hygroscopicity. In addition, branched-chain alcohols have higher octane numbers compared with their straight-chain counterparts. However, these alcohols cannot be synthesized economically using native organisms. Here we present a metabolic engineering approach using Escherichia coli to produce higher alcohols including isobutanol, 1-butanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from glucose, a renewable carbon source. This strategy uses the host's highly active amino acid biosynthetic pathway and diverts its 2-keto acid intermediates for alcohol synthesis. In particular, we have achieved high-yield, high-specificity production of isobutanol from glucose. The strategy enables the exploration of biofuels beyond those naturally accumulated to high quantities in microbial fermentation.

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1,813 citations


Journal ArticleDOI
Sang Yup Lee1, Jin Hwan Park1, Seh Hee Jang1, Lars K. Nielsen2  +2 moreInstitutions (3)
TL;DR: This article reviews biotechnological production of butanol by clostridia and some relevant fermentation and downstream processes and the strategies for strain improvement by metabolic engineering and further requirements to make fermentative butanol production a successful industrial process.

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Abstract: Butanol is an aliphatic saturated alcohol having the molecular formula of C4H9OH Butanol can be used as an intermediate in chemical synthesis and as a solvent for a wide variety of chemical and textile industry applications Moreover, butanol has been considered as a potential fuel or fuel additive Biological production of butanol (with acetone and ethanol) was one of the largest industrial fermentation processes early in the 20th century However, fermentative production of butanol had lost its competitiveness by 1960s due to increasing substrate costs and the advent of more efficient petrochemical processes Recently, increasing demand for the use of renewable resources as feedstock for the production of chemicals combined with advances in biotechnology through omics, systems biology, metabolic engineering and innovative process developments is generating a renewed interest in fermentative butanol production This article reviews biotechnological production of butanol by clostridia and some relevant fermentation and downstream processes The strategies for strain improvement by metabolic engineering and further requirements to make fermentative butanol production a successful industrial process are also discussed Biotechnol Bioeng 2008;101: 209-228 © 2008 Wiley Periodicals, Inc

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949 citations


Journal ArticleDOI
Shota Atsumi1, Anthony F. Cann1, Michael R. Connor1, Claire R. Shen1  +5 moreInstitutions (1)
TL;DR: A synthetic pathway is engineered in Escherichia coli and the production of 1-butanol is demonstrated from this non-native user-friendly host, showing promise for using E. coli for 1- butanol production.

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Abstract: Compared to ethanol, butanol offers many advantages as a substitute for gasoline because of higher energy content and higher hydrophobicity. Typically, 1-butanol is produced by Clostridium in a mixed-product fermentation. To facilitate strain improvement for specificity and productivity, we engineered a synthetic pathway in Escherichia coli and demonstrated the production of 1-butanol from this non-native user-friendly host. Alternative genes and competing pathway deletions were evaluated for 1-butanol production. Results show promise for using E. coli for 1-butanol production.

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848 citations


Journal ArticleDOI
Peter Dürre1Institutions (1)
TL;DR: The best‐studied bacterium to perform a butanol fermentation is Clostridium acetobutylicum, and its genome has been sequenced, and the regulation of solvent formation is under intensive investigation, opening the possibility to engineer recombinant strains with superior biobutanol‐producing ability.

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Abstract: Biofuels are an attractive means to prevent a further increase of carbon dioxide emissions. Currently, gasoline is blended with ethanol at various percentages. However, butanol has several advantages over ethanol, such as higher energy content, lower water absorption, better blending ability, and use in conventional combustion engines without modification. Like ethanol, it can be produced fermentatively or petrochemically. Current crude oil prices render the biotechnological process economic again. The best-studied bacterium to perform a butanol fermentation is Clostridium acetobutylicum. Its genome has been sequenced, and the regulation of solvent formation is under intensive investigation. This opens the possibility to engineer recombinant strains with superior biobutanol-producing ability.

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834 citations


Journal ArticleDOI
Chao Jin1, Mingfa Yao1, Haifeng Liu1, Chia-Fon Lee2  +2 moreInstitutions (3)
Abstract: Butanol is a very competitive renewable biofuel for use in internal combustion engines given its many advantages. In this review, the properties of butanol are compared with the conventional gasoline, diesel fuel, and some widely used biofuels, i.e. methanol, ethanol, biodiesel. The comparison of fuel properties indicates that n-butanol has the potential to overcome the drawbacks brought by low-carbon alcohols or biodiesel. Then, the development of butanol production is reviewed and various methods for increasing fermentative butanol production are introduced in detailed, i.e. metabolic engineering of the Clostridia, advanced fermentation technique. The most costive part of the fermentation is the substrate, so methods involved in renewed substrates are also mentioned. Next, the applications of butanol as a biofuel are summarized from three aspects: (1) fundamental combustion experiments in some well-defined burning reactors; (2) a substitute for gasoline in spark ignition engine; (3) a substitute for diesel fuel in compression ignition engine. These studies demonstrate that butanol, as a potential second generation biofuel, is a better alternative for the gasoline or diesel fuel, from the viewpoints of combustion characteristics, engine performance, and exhaust emissions. However, butanol has not been intensively studied when compared to ethanol or biodiesel, for which considerable numbers of reports are available. Finally, some challenges and future research directions are outlined in the last section of this review.

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736 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20226
2021202
2020256
2019279
2018300
2017356

Top Attributes

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Topic's top 5 most impactful authors

Nasib Qureshi

42 papers, 5.6K citations

Shang-Tian Yang

38 papers, 2.1K citations

Chuang Xue

26 papers, 1K citations

Thaddeus Chukwuemeka Ezeji

22 papers, 3.6K citations

Antonio Marzocchella

19 papers, 421 citations