Topic
Cadmium chloride
About: Cadmium chloride is a research topic. Over the lifetime, 3060 publications have been published within this topic receiving 63113 citations. The topic is also known as: CdCl2 & [CdCl2].
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TL;DR: In the present experiment, the seeds of Cicer arietinum (L.) cv.
212 citations
TL;DR: Results clearly indicate that low dose chronic administration of sodium dichromate and cadmium chloride induces an oxidative stress resulting in tissue damaging effects that may contribute to the toxicity and carcinogenicity of these two cations.
209 citations
TL;DR: Lung cancers were induced in inbred W rats by cadmium chloride aerosols by inducing a dose-dependent incidence of primary lung carcinomas of the following types: adenocarcinomas, epidermoid (squamous cell) carcinomas, combined epidersmoid carcinomas and adenOCarcinoma, and mucoepidermoids carcinomas.
Abstract: Lung cancers were induced in inbred W rats by cadmium chloride aerosols. For 18 months, 120 male W rats were continuously exposed to cadmium chloride aerosols with cadmium (Cd) concentrations of 12.5, 25, and 50 micrograms/m3, respectively. For the same period of time, 41 rats were kept in filtered air; these rats served as the control group. The survivors were killed 13 months after the end of the inhalation experiments. Histopathologic examination revealed a dose-dependent incidence of primary lung carcinomas of the following types: adenocarcinomas, epidermoid (squamous cell) carcinomas, combined epidermoid carcinomas and adenocarcinomas, and mucoepidermoid carcinomas. The incidence of lung carcinomas was 71.4% in the group exposed to 50 micrograms Cd/m3, 52.6% in the group exposed to 25 micrograms Cd/m3, and 15.4% in the group exposed to 12.5 micrograms Cd/m3. None of the controls developed lung carcinomas. At the end of the experiment, the remaining Cd concentrations in the lungs were relatively high, almost at the same level as those in the livers.
206 citations
Journal Article•
TL;DR: It was shown that Cadmium-metallothionein complex injected into mice results in higher cadmium levels in renal cortex and more severe renal tubular cell injury than a comparable dose of cadMium chloride administered by the same route.
Abstract: Cadmium-induced metallothionein may have a paradoxical role in the pathogenesis of cadmium toxicity. Mice are protected from cadmium-induced testicular necrosis by metallothionein, but in this experiment it was shown that cadmium-metallothionein complex injected into mice results in higher cadmium levels in renal cortex and more severe renal tubular cell injury than a comparable dose of cadmium chloride administered by the same route. Also, an injection of 1.1 mg/kg of body weight or more of cadmium bound to metallothionein was fatal to male CGA mice within seven days whereas five times this dose of cadmium administered as cadmium chloride was needed to produce a similar effect. A reason for the difference in renal effects of these two forms of cadmium has not been determined but may be related to differences in absorption or transport by renal tubular lining cells.
201 citations
TL;DR: Cadmium causes renal toxicity by inducing lipid peroxidation, decreasing antioxidant systems, and also by altering lipid metabolism, and selenium treatment could protect the kidney tissues against the toxicity of cadmium since it reduced MDA levels and increased the activities of antioxidant enzymes in these tissues.
195 citations